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UnknownReceptor tyrosine kinase (RTK) mediated tyrosine phosphor-proteome from Drosophila S2 (ErbB1) cells reveals novel signaling networks.
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S-EPMC2488400 | biostudies-literature
ProteomicsPhosphoScan profiling of tyrosine phosphorylation in crizotinib-resistant PDX tumors
we generated patient-derived xenograft crizotinib-resistant mice and subjected them to phosphorylation profiling, together with crizotinib-resistant mice treated with ASP3026 or alectinib
ORGANISM(S): Homo Sapiens 
PXD054055 |
ProteomicsPhospho-tyrosine proteomic analysis in Ptprd-meB+/– mice
PTPδ, encoded by PTPRD, is implicated in various neurological, psychiatric, and neurodevelopmental disorders, but the underlying mechanisms remain unclear. PTPδ trans-synaptically interacts with multiple postsynaptic adhesion molecules, which involves its extracellular alternatively spliced mini-exo...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-01 | PXD053554 | Pride
Phospho-tyrosine proteomic analysis Ptprd-meb Lc-ms/ms 
ProteomicsDYRK1A, a potential therapeutic target for head and neck squamous cell carcinoma
To identify the activated tyrosine kinase signaling pathways in HNSCC, we carried out phosphotyrosine profiling using a panel of HNSCC cell lines compared to a normal oral keratinocyte. A total of 61 unique phosphosites were identified across these cell lines. Dual-specificity tyrosine-(Y)-phosphor...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002132 | Pride
Dual specificity kinases Head and neck squamous cell carcinoma Phosphoproteomics 
ProteomicsThe EML4-ALK Interactome in Lung Cancer
We experimentally generated an ALK interactome combining quantitative tyrosine phosphoproteomics and protein complex annotation using affinity purification coupled with mass spectrometry and further investigated downstream ALK signaling using quantitative tyrosine phosphoproteomics.
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD004935 | Pride
Human Eml4-alk Interactome Lung cancer 
ProteomicsThe ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5
Ataxia telangiectasia mutated (ATM) is a protein that belongs to the family of phosphatidylinositol 3-kinase (PI3K)-like serine/threonine kinases. Initially identified as a nuclear protein essential for the DNA damage response (DDR) in mitotic cells, it serves as repair coordinator for DNA double-st...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-09-29 | PXD058394 | Pride
Taxol Sodium arsenite Coimmunoprecipitation Differential ultracentrifugation Label-free mass spectrometry Chloroquine Immobilized metal affinity chromatography Phosphoscan 
ProteomicsA quantitative phosphoproteomic analysis to study the dynamics of tyrosine phosphorylation in EGFR signaling abrogated by TKIs
Lung cancer is the leading cause of cancer death. Mutations in the kinase domain of EGFR, a predominant driver oncogene, such as L858R missense mutation and a series of deletions spanning the conserved sequence 747LREA750, are associated with sensitivity to tyrosine kinase inhibitors (TKIs). However...
ORGANISM(S): Homo sapiens (Human) 
2017-03-29 | PXD004373 | Pride
Nsclc Phosphoproteomics Tki Egfr Adenocarcinoma 
ProteomicsGlobal proteome and phosphoproteome alterations in 3rd generation EGFR TKI resistance reveal drug targets to circumvent resistance
Lung cancer continues to be the leading cause of cancer mortality worldwide. The treatment of lung cancer patients harboring mutant EGFR with orally administered EGFR TKIs has been a paradigm shift. Osimertinib and rociletinib are two 3rd generation irreversible EGFR TKIs targeting the EGFR T790M mu...
ORGANISM(S): Homo sapiens (Human) 
2021-03-11 | PXD020108 | Pride
Resistance mechanism Lung adenocarcinoma 3rd generation egfr tki 
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