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GenomicsComparative Analysis of Alkyne- and Desthiobiotinylated Photoaffinity Probes for Chemotranscriptomic Profiling
Comparative Analysis of Alkyne- and Desthiobiotinylated Photoaffinity Probes for Chemotranscriptomic Profiling
PRJNA1416391 | ENA
TranscriptomicsComparative Analysis of Alkyne- and Desthiobiotinylated Photoaffinity Probes for Chemotranscriptomic Profiling
Understanding small molecule-RNA interactions is a crucial part in drug development and fundamental biology. Chemotranscriptomic profiling is emerging as a powerful platform to interrogate interactions of small molecules with entire transcriptomes. This technique relies on photoaffinity probes that ...
ORGANISM(S): Escherichia coli 
2026-03-18 | GSE318057 | GEO
ProteomicsActivity-based protein profiling in human M2 macrophages using DHA-based photoaffinity probes
17-Hydroxydocosahexaenoic acid (17-HDHA), an oxidative metabolite of the fish oil constituent docosahexaenoic acid (DHA, 22:6 n-3), is a signaling lipid with anti-inflammatory properties. The molecular mechanisms underlying the biological effect of 17-HDHA are poorly understood. Here, we report the ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-28 | PXD027600 | Pride
Human Abpp Photoaffinity Macrophage 
ProteomicsProteome selectivity profiling of photoaffinity probes derived from imidazopyrazine-kinase inhibitors
Kinases are attractive drug targets, but the design of highly selective kinase inhibitors remains challenging. Selectivity may be evaluated against a panel of kinases, or – preferred – in a complex proteome. Probes that allow photoaffinity-labeling of their targets can facilitate this process. Here,...
ORGANISM(S): Homo sapiens (Human) 
2024-10-28 | PXD053278 | Pride
Kinase inhibitors Imidazopyrazines Photoaffinity labeling 
ProteomicsDevelopment of nucleus-targeted synthetic histone photoaffinity probes
Dissection of the physiological interactomes of histone post-translational modifications (hPTMs) is crucial for understanding fundamental epigenetic regulatory pathways. Current peptide- or protein-based histone photoaffinity probes have greatly expanded the ability to probe the epigenetic interacto...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-21 | PXD045620 | Pride
Nucleus-targeted histone photoaffinity probe Lactylation The epigenetic interactome Hard-to-transfect cells Native cells 
ProteomicsChemical probes unravel an antimicrobial defense response triggered by binding of the human opioid dynorphin to a bacterial sensor kinase
Host-microbe communication via small molecule signals is often poorly understood at the molecular level. Under conditions of host stress, levels of the human opioid peptide dynorphin are elevated, triggering virulence in the opportunistic pathogenic bacterium Pseudomonas aeruginosa (PAO1) via an unk...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2017-04-03 | PXD006172 | Pride
Photoaffinity probes Host-microbe communication Pseudomonas aeruginosa 
ProteomicsIdentification of Mono-ADP-Ribose Readers Using Well-Defined Photoaffinity-based Probes
In this study, well-defined photoaffinity-based monoADPr probes (biotin-linked) were synthesized and used to study direct interactors of monoADPr. Either a benzophenone or diazirine group was incorporated to assess their performance in enriching for known mnonoADPr readers. To ensure only monoADPr r...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD065574 | Pride
Astral Monoadpr Adp-ribosylation 
ProteomicsLinear vs Spirocyclic Dialkyldiazirine Probes for Photoaffinity Labeling
Dialkyldiazirines have emerged as a photoaffinity probe of choice for interactome mapping in live cell experiments. Upon irradiation, ‘linear’ dialkyldiazirines produce dialkylcarbenes, which are susceptible to both intramolecular reactions and unimolecular elimination processes, as well as diazoalk...
ORGANISM(S): Homo sapiens (Human) 
2024-10-13 | PXD052768 | Pride
Photoaffinity 
UnknownPhotoaffinity probes for nematode pheromone receptor identification.
Not available
S-EPMC6961461 | biostudies-literature
UnknownProteome selectivity profiling of photoaffinity probes derived from imidazopyrazine-kinase inhibitors.
Not available
S-EPMC11799219 | biostudies-literature
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