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TranscriptomicsCombined miRNA and mRNA Sequencing Identifies Protective Transcriptional Signature of Enhanced PI3Kalpha Signaling in Cardiac Hypertrophy
A molecular and bioinformatic pipeline permitting comprehensive analysis and quantification of myocardial miRNA and mRNA expression with next-generation sequencing was developed and the impact of enhanced PI3Kalpha signaling on the myocardial transcriptome signature of pressure overload-induced path...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-35350 | biostudies-arrayexpress
TranscriptomicsCombined miRNA and mRNA Sequencing Identifies Protective Transcriptional Signature of Enhanced PI3Kalpha Signaling in Cardiac Hypertrophy
A molecular and bioinformatic pipeline permitting comprehensive analysis and quantification of myocardial miRNA and mRNA expression with next-generation sequencing was developed and the impact of enhanced PI3Kalpha signaling on the myocardial transcriptome signature of pressure overload-induced path...
ORGANISM(S): Mus musculus 
2013-05-01 | GSE35350 | GEO
UnknownSomatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design.
Not available
S-EPMC2821964 | biostudies-literature
UnknownA frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.
Not available
S-EPMC2761334 | biostudies-literature
ProteomicsPI3Kalpha Immunocomplex Identification
Mass Spectrometry Analysis of PI3Ka Immunocomplex via immunoprecipitation and SDS-PAGE separation
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD021306 | Pride
P85alpha antibody Pi3kalpha Immunoprecipitation Map4 protein 
GenomicsMus musculus
Combined miRNA and mRNA Sequencing Identifies Protective Transcriptional Signature of Enhanced PI3Kalpha Signaling in Cardiac Hypertrophy
PRJNA152727 | ENA
UnknownNon-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.
Not available
S-EPMC2797144 | biostudies-literature
UnknownDiscovery and SAR of Novel Disubstituted Quinazolines as Dual PI3Kalpha/mTOR Inhibitors Targeting Breast Cancer.
Not available
S-EPMC7667832 | biostudies-literature
ProteomicsPhosphoproteomics of BYL719 (alpelisib)-Resistant T47D Human Breast Cancer Cell Line
The PI3Kalpha-specific inhibitor Alpelisib (BYL719) has been approved for the treatment of metastatic ER+/HER2- breast cancer patients in combination with Fulvestrant. After initial response, patients develop drug resistance and disease relapses. In order to identify signalling pathways contributing...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD033956 | Pride
Targeted therapies Human breast cancer Pi3k Byl719 Phosphoproteomics Alpelisib 
ProteomicsHDX-MS of Activators and Inhibitors of PI3Kalpha
Harnessing the potential beneficial effects of kinase signalling through the generation of direct kinase activators remains an underexplored area of drug development. This also applies to the PI 3-kinase (PI3K) signalling pathway which has been extensively targeted by inhibitors for conditions with ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD037721 | Pride
Pi3ka Ucl-1938-tro Hdx-ms P110a 
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