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GenomicsSARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified non-synonymous mutations in MHC-I restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding...
EGAS00001005060 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
Genomics5c638551-978c-4e80-b87e-d669d6b7069e - samples
Full information about the T cell receptor (CR) variable regions found in the sequences of the vdj region. Columns: barcode is_cell contig_id high_confidence length chain v_gene d_gene j_gene c_gene full_length productive cdr3 cdr3_nt reads umis raw_clonotype_id raw_consensus_id
EGAD00001008109 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
Genomics5a9f4bd6-d795-47e9-9690-979bf5b1df6b - samples
The data contains single-cell gene sequencing data (10x Genomics) from FACS-purified CD8 T lymphocytes from two Austrian patients. The cells were stimulated with one MHC class I peptides obtained from a common (wild type) variant and an emerging mutant variant of the SARS-Cov-2 virus. Then the samp...
EGAD00001006995 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
ProteomicsEffects of dexamethasone on the testicular proteome of Callithrix jacchus
To investigate effects of dexamethasone on the testis, we performed organotypic incubations of testicular fragments of Callithrix jacchus.
ORGANISM(S): Callithrix jacchus 
2026-08-24 | PXD050900 | Pride
Callithrix jacchus Dexamethasone Testis 
GenomicsCCRI COVID Patient Data Access Committee
Data Access Committee EGAC00001001989
EGAC00001001989 | EGA
ProteomicsDexamethasone is a regulator of human testicular peritubular cells / Secretome Data
The functions of human testicular peritubular cells (HTPCs), which form a small compartment located between the seminiferous epithelium and the interstitials areas of the testis, go beyond intratesticular sperm transport and include immunological roles. The expression of the glucocorticoid receptor ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033504 | Pride
Human male fertility  human testis  dexamethasone  cytokines  inflammation  proteomics 
ProteomicsDexamethasone is a regulator of human testicular peritubular cells / Proteome 24 h
The functions of human testicular peritubular cells (HTPCs), which form a small compartment located between the seminiferous epithelium and the interstitials areas of the testis, go beyond intratesticular sperm transport and include immunological roles. The expression of the glucocorticoid receptor ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033514 | Pride
Human male fertility  human testis  dexamethasone  cytokines  inflammation  proteomics 
ProteomicsDexamethasone is a regulator of human testicular peritubular cells / Proteome 72 h
The functions of human testicular peritubular cells (HTPCs), which form a small compartment located between the seminiferous epithelium and the interstitials areas of the testis, go beyond intratesticular sperm transport and include immunological roles. The expression of the glucocorticoid receptor ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033534 | Pride
Human male fertility  human testis  dexamethasone  cytokines  inflammation  proteomics 
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