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Proteomicsp97/VCP is required for piecemeal autophagy of aggresomes
Metazoan cells adapt to the exhaustion of protein quality control (PQC) systems by sequestering aggregation-prone proteins in large, pericentriolar structures termed aggresomes. Defects in both, aggresome formation and clearance affect proteostasis and have been linked to neurodegenerative diseases,...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD053581 | Pride
Aggrephagy Proximity proteomics Turboid Protein quality control Tax1bp1 P97/vcp Piecemeal autophagy 
UnknownAutophagosome development and chloroplast segmentation occur synchronously for piecemeal degradation of chloroplasts.
Not available
S-EPMC11542923 | biostudies-literature
UnknownThe multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum.
Not available
S-EPMC4028325 | biostudies-literature
UnknownSNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics.
Not available
S-EPMC11893173 | biostudies-literature
UnknownPiecemeal microautophagy of the nucleus requires the core macroautophagy genes.
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S-EPMC2555948 | biostudies-literature
UnknownSAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components.
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S-EPMC8160579 | biostudies-literature
UnknownQuaternary structures of Vac8 differentially regulate the Cvt and PMN pathways.
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S-EPMC7469494 | biostudies-literature
UnknownLive while the DNA lasts. The role of autophagy in DNA loss and survival of diploid yeast cells during chronological aging.
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S-EPMC10599738 | biostudies-literature
UnknownInfection-associated nuclear degeneration in the rice blast fungus Magnaporthe oryzae requires non-selective macro-autophagy.
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S-EPMC3308974 | biostudies-literature
UnknownA chaperone-proteasome-based fragmentation machinery is essential for aggrephagy.
Not available
S-EPMC12431860 | biostudies-literature
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