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UnknownDevelopment of combinatorial antibody therapies for diffuse large B cell lymphoma.
Not available
S-EPMC9637670 | biostudies-literature
UnknownEffects of Prior Infection with SARS-CoV-2 on B Cell Receptor Repertoire Response during Vaccination.
Not available
S-EPMC9506540 | biostudies-literature
ProteomicsSlowing prion disease via M1 muscarinic receptors is associated with reduced neuroinflammation and down-regulation of neurodegenerative disease markers
Currently there are no treatments that can slow or halt the progression of dementia’s including Alzheimer’s disease. Here we investigate the possibility that activation of the M1-muscarinic receptor (M1-receptor), which is highly expressed in the brain and that shows pro-cognitive properties, might ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-14 | PXD025561 | Pride
G protein-coupled receptor Alzheimer’s disease Neuroinflammation Warwick_rtp Positive allosteric modulators Transcriptomic Prion disease Proteomic Neurodegeneration Neurodegenerative disease M1 muscarinic acetylcholine receptor 
ProteomicsSARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner
Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in human primary adipose-derived stromal-vascular cells ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034510 | Pride
Lipolysis Inflammation Sars-cov-2 Fat depots Adipose tissue Covid-19 Obesity Visceral fat Virus attenuation Variants of concern 
ProteomicsProteomics for Roseburia intestinalis and Parabacteroides merdae exposed to isosteviol and duloxetine.
The objective of this project was to identify changes in protein expression in R. intestinalis and P. merdae as a response to the treatment with the antidepressant duloxetine, the sweetener isosteviol and a combination of both. 18 samples before and after treatment were collected for each of the two...
ORGANISM(S): Parabacteroides merdae Roseburia intestinalis 
2026-04-30 | PXD045140 | Pride
Proteomics Antidepressant duloxetine Gut bacteria Sweetener isosteviol 
ProteomicsVAMP2/3-dependent membrane proteome in oligodendrocytes
Which proteins in oligodendrocytes require VAMP2/3-mediated exocytosis for membrane trafficking? We isolated primary oligodendrocytes from transgenic mice expressing oligodendrocyte-targeted botulinum toxin and littermate controls and used surface biotinylation to determine which proteins were diffe...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD036174 | Pride
Myelin Oligodendrocytes 
ProteomicsBenchmark dataset relating to Kamrad et al "Interspecies interactions drive bacterial proteome reorganisation and emergent metabolism"
Three co-cultures containing gram-positive and -negative species at different ratios (1:1 to 1:9) were measured in quadruplicates, as well as the same number of corresponding mono-cultures. To isolate LC-MS matrix effects in the absence of biological proteome changes, we mixed mono-culture samples i...
ORGANISM(S): Bacteroides thetaiotaomicron Agathobacter rectalis Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2026-02-02 | PXD072524 | Pride
Gut bacteria Synthetic communities Microbiome 
ProteomicsKamrad et al Interspecies interactions drive proteome reorganization and emergent metabolism in gut bacteria"
Inter-species interactions shape the function and dynamics of microbial communities. Yet, the understanding of how these interactions influence the molecular physiology of interacting species remains surprisingly limited. Here, we assembled 104 synthetic pairwise co-cultures of 15 diverse gut bacter...
ORGANISM(S): Phocaeicola vulgatus Segatella copri Bacteroides uniformis Parabacteroides merdae Clostridium sporogenes Bacteroides thetaiotaomicron Bacteria Lactobacillus acidophilus [Clostridium] saccharolyticum Ruminococcus gnavus Lactobacillus gasseri Escherichia coli Collinsella aerofaciens Klebsiella aerogenes Clostridioides difficile Agathobacter rectalis 
2025-05-12 | PXD055395 | Pride
C. difficile Metaproteomics Microbiome 
UnknownDevelopment of a reef fish biological condition gradient model with quantitative decision rules for the protection and restoration of coral reef ecosystems.
Not available
S-EPMC8717739 | biostudies-literature
UnknownThe major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
Not available
S-EPMC3235490 | biostudies-literature
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