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TranscriptomicsHuman Argonaute Immunoaffinity Purification-associated RNA
Immunoaffinity Purifications of Human Argonaute Twelve hours after transfections with mock or with miR-124, we washed each 15-cm plate once with phosphate-buffered saline (usually two plates were used per IP), then added 1 ml of 4 C lysis buffer (150 mM KCl, 25 mM Tris-HCl [pH 7.4], 5 mM Na-EDTA [p...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-18834 | biostudies-arrayexpress
UnknownActivation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer.
Not available
S-EPMC8770594 | biostudies-literature
MetabolomicsFate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics.
The biological effects of the pesticide and mitochondrial complex I inhibitor tebufenpyrad (TEBU) on liver cells were investigated by combining proteomics and metabolomics. Both cell culture media and cellular lysates were analyzed in dose-response and kinetic experiments on the HepaRG cell line. Re...
2024-02-07 | MTBLS4063 | MetaboLights
ProteomicsSyntaxin 4 (STX4) protects islet -cells from cytokine-induced senescence
Syntaxin 4 (STX4) is a plasma membrane SNARE protein known to facilitate insulin granule exocytosis in pancreatic β-cells. Recent studies have uncovered that STX4 also exerts protective effects against inflammatory and metabolic stress by stabilizing mitochondrial function and suppressing NF-κB acti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-25 | PXD069706 | Pride
Sasp Inflammation Stx4 Type 1 diabetes Beta cell senescence 
TranscriptomicsTherapeutic interference with mTorc1 restricts inflammation-associated and Stat3-dependent gastro-intestinal tumourigenesis in mice
Gp130 receptor engagement on neoplastic cells provides a link by which an inflammatory microenvironment facilitates tumour promotion. Although hyperactivation of the gp130-dependent Stat3 signalling node is commonly observed in solid tumours, Stat3 remains a challenging therapeutic target. To mimic ...
ORGANISM(S): Mus musculus 
2013-01-29 | E-GEOD-35808 | biostudies-arrayexpress
ProteomicsRelease of the plant peptide hormone PEP1 from its precursor PROPEP1 in response to physical damage is due to Ca2+-dependent activation of METACASPASE4.
Physical damage to cells leads to the release of immunomodulatory peptides in order to elicit wound defense responses in the surrounding tissue. In Arabidopsis thaliana, the intracellular PROPEP1 protein precursor is processed into the mature 2.5 kDa PEP1 before release. However, the maturation mech...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-04-18 | PXD010816 | Pride
Arabidopsis Protease Metacaspase4 Proteolysis Propep Physical damage 
ProteomicsUsing global proteomics to investigate the effect of IQDMA treatment on Leukemic forms of cutaneous T-cell lymphomas (L-CTCL) cells
Leukemic cutaneous T-cell lymphomas (L-CTCL) are lymphoproliferative disorders of skin-homing mature T-cells causing chronic inflammation, tissue destruction, severe infections and sepsis, all linked to poor quality of life and high mortality. Despite numerous sequencing efforts in L-CTCL, recurrent...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035626 | Pride
Global proteomics Kinase Cutaneous t-cell lymphomas (l-ctcl) 
ProteomicsUsing global proteomics to investigate the effect of IQDMA treatment on Leukemic forms of cutaneous T-cell lymphomas (L-CTCL) cells
Leukemic cutaneous T-cell lymphomas (L-CTCL) are lymphoproliferative disorders of skin-homing mature T-cells causing chronic inflammation, tissue destruction, severe infections and sepsis, all linked to poor quality of life and high mortality. Despite numerous sequencing efforts in L-CTCL, recurrent...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD035699 | Pride
Cutaneous t-cell lymphoma Kinases 
ProteomicsComprehensive proteomic analysis of human erythropoiesis - experiment 4 over 4
We performed a proteomic analysis of human erythropoiesis using 4 umbilical cord's blood samples. This study revealed the absolute and quantitative expression of more than 6000 proteins throughout 7 stages of erythroid differentiation using a label-free technique. We found new informations on erythr...
ORGANISM(S): Homo sapiens (Human) 
2016-08-08 | PXD004316 | Pride
Label-free itraq pyrenocyte reticulocyte erythroblast differentiation human hematopoiesis q-exactive 
ProteomicsComprehensive proteomic analysis of human erythropoiesis - experiment 3 over 4
We performed a proteomic analysis of human erythropoiesis using 4 umbilical cord's blood samples. This study revealed the absolute and quantitative expression of more than 6000 proteins throughout 7 stages of erythroid differentiation using a label-free technique. We found new informations on erythr...
ORGANISM(S): Homo sapiens (Human) 
2016-08-08 | PXD004315 | Pride
Label-free itraq pyrenocyte reticulocyte erythroblast differentiation human hematopoiesis q-exactive 
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