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MetabolomicsA chromosome-level genome assembly and multi-omics analyses provide insights into the biosynthesis of piperlongumine in Piper sarmentosum

Piper sarmentosum Roxb. is a significant medicinal and edible plant, and its active compound piperlongumine (PL) has garnered attention due to its pharmacological activities, including anticancer and anti-inflammatory effects. However, the key enzymes and regulatory mechanisms of its biosynt...

2025-12-17 | MTBLS13523 | MetaboLights
ProteomicsPiperlongumine (PL) conjugates induce targeted protein degradation
PROteolysis Targeting Chimeras (PROTACs) are bifunctional molecules that degrade target proteins through recruiting E3 ligases. However, their application is limited in part because few E3 ligases can be recruited by known E3 ligase ligands. In this study, we identified piperlongumine (PL), a natura...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039385 | Pride
Piperlongumine Protac E3 ligase Cdk9 
GenomicsExpression data from piperlongumine treated bladder cancer T24 cells
Expression data from piperlongumine treated bladder cancer T24 cells
PRJNA413628 | ENA
GenomicsExpression data from piperlongumine treated bladder cancer T24 cells
Piperlongumine (PL), a natural alkaloid isolated from longer pepper plants, is recently found to be a potent selective anti-cancer compound. To further explore the therapeutic spectrum and molecular mechanisms of PL, we tested its anti-cancer effects in bladder cancer, the fifth most common and aggr...
ORGANISM(S): synthetic construct Homo sapiens 
2019-10-01 | GSE104717 | GEO
GenomicsPiperlongumine (PL) conjugates induce targeted protein degradation
Piperlongumine (PL) conjugates induce targeted protein degradation
PRJNA851461 | ENA
GenomicsPiperlongumine attenuates osteoarthritis progression by eliminating senescent meniscus cells and chondrocytes
Piperlongumine attenuates osteoarthritis
PRJEB100541 | ENA
GenomicsAllosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
PRJNA544318 | ENA
UnknownPiperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1).
Not available
S-EPMC10551445 | biostudies-literature
UnknownImpact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines.
Not available
S-EPMC4162141 | biostudies-literature
UnknownPiperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells.
Not available
S-EPMC5341994 | biostudies-literature
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