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ProteomicsTunneling nanotubes contribute to the stroma-mediated imatinib resistance of leukemic cells
Intercellular communication within the bone marrow niche significantly influences leukemogenesis and the sensitivity of leukemic cells to therapy. However, the landscape of possible cell-cell interactions is still incomplete. Tunneling nanotubes (TNTs) are a novel mode of intercellular cross-talk. T...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD011013 | Pride
Leukemic cells Silac Human Nanotubues 
ProteomicsTunneling nanotubes contribute to the stroma-mediated imatinib resistance of leukemic cells DID
Intercellular communication within the bone marrow niche significantly influences leukemogenesis and the sensitivity of leukemic cells to therapy. However, the landscape of possible cell-cell interactions is still incomplete. Tunneling nanotubes (TNTs) are a novel mode of intercellular cross-talk. T...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD013504 | Pride
Lc-ms Bone marrow Qexatoive 
Proteomicsproteomic profiling of small extracellular vesicles (EVs), released by chronic myeloid leukemia cells K562
Chronic and acute myeloid leukemia (CML/AML) evade immune surveillance and induce immunosuppression, largely by upregulating Foxp3+ regulatory T cells (Treg). However, mechanisms that drive Treg in myeloid leukemias are largely unknown. Here, we show that leukemic (CML- and AML-derived) extracellula...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD027240 | Pride
Leukemia K562 Extracelluar vesicles Evs 
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