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ProteomicsA unique and divergent cyclin/cyclin-dependent kinase complex controls DNA replication during atypical cell-cycles of Plasmodium berghei gametogonyA unique and divergent cyclin/cyclin-dependent kinase complex controls DNA replication during atypical cell-cycles of Plasmodium berghei gametogony
Cell-cycle transitions are generally triggered by variations in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria parasites express ancestral CDKs and cyclins, whose functions and interdependency remain elusive. Here, we show that the unique Plasmodium berghei CDK-related kin...
ORGANISM(S): Plasmodium berghei ANKA 
2020-02-18 | PXD017283 | Pride
Lc-msms Plasmodium berhei Tmt10 Phosphorylation Cyclin-dependent kinase 
ProteomicsReal-time dynamics of Plasmodium Ndc80 reveals unusual modes of chromosome segregation during parasite proliferative stages
Eukaryotic cell proliferation requires chromosome replication and precise segregation to ensure daughter cells have identical genomic copies. The genus Plasmodium, the causative agent of malaria, has developed remarkable characteristic of nuclear division throughout its lifecycle to meet some peculi...
ORGANISM(S): Plasmodium berghei ANKA 
2020-06-09 | PXD017619 | Pride
Ndc80 Chromosome segregation Malaria Parasite Proliferation Warwick-rtp Plasmodium 
ProteomicsProtein Phosphatase 1 regulates atypical chromosome segregation and cell polarity during mitotic and meiotic division in Plasmodium sexual stages
PP1 is a conserved eukaryotic serine/threonine phosphatase that regulates many aspects of mitosis and meiosis, often working in concert with other phosphatases, such as CDC14 and CDC25. The proliferative stages of the parasite life cycle include sexual development within the mosquito vector, with ma...
ORGANISM(S): Plasmodium berghei ANKA 
2021-09-10 | PXD023571 | Pride
Cell division Kinetochore Phosphatase Polarity Sexual stage Warwick-rtp Plasmodium 
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