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ProteomicsIdentifying the mitotic interactome of the human PLK1 protein kinase
The project mapped the interactors of PLK1 in cells were the endogenous PLK1 locus was tagged with 3xHA tags. Cells were arrested in mitosis with nocodazole and treated with a PLK1 inhibitor (BI-2536) to trap PLK1 onto its substrates, facilitating detection by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD080479 | Pride
Plk1 mitotic interactome 
ProteomicsProteomic Analysis of a PLK1-Dependent, Cell Cycle Degradation Program
Targeted protein degradation by the ubiquitin-proteasome system is an essential mechanism regulating cellular division. The kinase PLK1 coordinates protein degradation at the G2/M phase of the cell cycle by promoting the binding of substrates to the E3 ubiquitin ligase SCFβTrCP. However, the magnitu...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046039 | Pride
Degradation Plk1 Cell cycle Ubiquitin 
UnknownProteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.
Not available
S-EPMC1864981 | biostudies-literature
ProteomicsThe functional antagonism between SIRT2 and MOF regulates mitotic entry - MOF interactors
Mitosis entry is tightly regulated by a complex network of interconnected mechanisms involving epigenetic modifications, signaling pathways, transcriptional control, and structural changes. While significant progress has been made in understanding these processes individually, the mechanisms integra...
ORGANISM(S): Homo sapiens (Human) 
2026-04-29 | PXD065214 | Pride
Fusion lumos Plk1 Mof Sirt2 Interactome Label free 
ProteomicsMyotubularin-related proteins control abscission_StDenis_MTMR_P84_VS6-7-8-11-12
This submission is part of the mass spectrometry datasets for the manuscript by St-Denis et al. entitled: Myotubularin-related proteins 3 & 4 interact with PLK1 and CEP55 to control CEP55 recruitment to the midbody and ensure proper abscission. This submission contains 82 RAW files and 82 mgf files...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-10-30 | MSV000078915 | MassIVE
UnknownProteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control.
Not available
S-EPMC10592729 | biostudies-literature
UnknownSorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis.
Not available
S-EPMC3888430 | biostudies-literature
UnknownIdentification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types.
Not available
S-EPMC6685999 | biostudies-literature
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