Sort   by:  
 Page size 
ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: PLK1 PRM
The aim of these experiments was to quantify PLK1 tyrosine phosphosites with respect to EYA4 and EYA1. PRM was performed on immunopurified PLK1. This was part of a larger project to characterize the effects of EYA4 mediated dephosphorylation on PLK1 functions.
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD037064 | Pride
Plk1 prm 
ProteomicsMass spectrometry analysis of in vitro PLK1 phosphorylation
Polo-like kinase 1 (PLK1) protects against genome instability by ensuring timely and accurate mitotic cell division, and its activity is tightly regulated throughout the cell cycle. Although the pathways that initially activate PLK1 in G2 are well-characterized, the factors that directly regulate PL...
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD053933 | Pride
Kinase Prm Phosphorylation 
ProteomicsDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are common in multiple types of human cancer and cause accumulation of the oncometabolite D-2-hydroxyglutarate (D2HG), which promotes tumor progression by noncovalently inhibiting α-ketoglutarate–dependent enzymes. Here we discovered covalent O...
ORGANISM(S): Homo sapiens (Human) 
2026-03-18 | PXD072530 | Pride
D2hg L2hg Ptm O-2-hydroxyglutarylation 
Sort   by:  
 Page size