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ProteomicsMonitoring post-translational modifications and associated proteomes of WT-PML-V and two mutants from acute promyelocytic leukaemia patients refractory for arsenic therapy: A216T-PML-V and L217F-PML-V
U2OS PML-/- cells were reconstituted with YFP-PML-V of three types: WT, A216T or L217F. These cell lines were used to purify YFP-PML bodies using anti-GFP nanobody beads from cells either treated or not with arsenic (1uM for 2h). Protein samples were monitored for PML post-translational modification...
ORGANISM(S): Homo sapiens (Human) 
2025-03-27 | PXD051743 | Pride
Pml arsenic sumo ubiquitin topors 
ProteomicsConcerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
Protein SUMOylation provides a principal driving force for cellular stress responses including DNA-protein crosslink (DPC) repair and arsenic-induced PML body degradation. In this study, using genome-scale screens, we identify the human E3 ligase TOPORS as a key effector of SUMO-dependent DPC resolu...
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD041717 | Pride
Rnf4 Stubl Crosstalk Ubiquitin Vcp Sumo Topors P97 
UnknownPML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways.
Not available
S-EPMC12002637 | biostudies-literature
UnknownConcerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation.
Not available
S-EPMC11402782 | biostudies-literature
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