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MetabolomicsMetabolomic Analysis Reveals an Important Role of Sphingosine 1-phosphate in the Development of HFMD due to EV-A71 Infection

Hand, foot, and mouth disease (HFMD) is a serious pediatric infectious disease that causes immeasurable physical and mental health burdens. Currently, there is a lack of information on the mechanisms of HFMD severity and early diagnosis. We performed metabolomic profiling of sera from 84 Enterovi...

2024-11-14 | MTBLS11656 | MetaboLights
ProteomicsOne way or another: Differential impact of pharmacologic inhibitors on extracellular vesicles derived from resting neutrophils
We performed a systematic investigation of seven pharmacologic inhibitors (calpeptin, D-pantethine, Y27632, cytochalasin D, GW4869, R5421, and Nexinhib20) on quantitative and qualitative EV properties derived from resting neutrophils. We measured EV numbers, size distribution, total lipid, protein, ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD069867 | Pride
Ev Exosome Pmn ev ms Neutrophil Extracellular vesicles 
UnknownProteomic Analysis of Salivary Extracellular Vesicles from COVID-19 Patients Reveals a Specific Anti-COVID-19 Response Protein Signature.
Not available
S-EPMC11011897 | biostudies-literature
ProteomicsImpact of high fat diet and platelet activation on pre-metastatic niche formation
Metastasis involves dynamic interactions between tumor cells and the tumor microenvironment. Obesity has emerged as a significant contributor to tumor progression, particularly in breast cancer (BC). This study explores the impact of obesity on BC metastasis, focusing on the role of platelets and th...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-22 | PXD051176 | Pride
Platelets Breast cancer Pre-metastatic niche Itraq High fat diet 
MetabolomicsUntargeted Metabolomics Analysis Reveals Aberrant Long-Chain Fatty Acids Metabolism in Relapsing-Remitting Multiple Sclerosisublication title

Background: Growing evidence indicates significant alterations in fatty acid metabolism in patients with relapsing-remitting multiple sclerosis (RRMS). However, the metabolic status of long-chain fatty acids (LCFAs), including mono-unsaturated fatty acids (MUFAs) and poly-unsaturated fatty acids ...

2026-03-23 | MTBLS13949 | MetaboLights
TranscriptomicsExtracellular vesicles isolated from human induced pluripotent stem cell-derived neurons contain a transcriptional network
Healthy brain function is mediated by several complementary signalling pathways, many of which are driven by extracellular vesicles (EVs). EVs are heterogeneous in both size and cargo and are constitutively released from cells into the extracellular milieu. They are subsequently trafficked to recipi...
ORGANISM(S): Homo sapiens 
2020-08-20 | E-MTAB-8254 | biostudies-arrayexpress
MetabolomicsMulti-omic Landscape of Airway Microbe-Host Interactions in Chronic Obstructive Pulmonary Disease

The mechanistic role of the airway microbiome in chronic obstructive pulmonary disease (COPD) remains largely unexplored. We present a landscape of airway microbe-host interactions in COPD by an in-depth profiling of sputum metagenome, metabolome, host transcriptome and proteome from 99 COPD pati...

2022-06-20 | MTBLS4017 | MetaboLights
TranscriptomicsTranscription profiling of mycelium and yeast cells of Paracoccidioides brasiliensis
Identification of differential mRNAs produced in the mycelium and yeast cells of Paracoccidioides brasiliensis
ORGANISM(S): Paracoccidioides brasiliensis 
2004-04-28 | E-MEXP-103 | biostudies-arrayexpress
MetabolomicsMultiomic analysis reveals a role of Fusobacterium periodonticum in colorectal tumorigenesis by decanoic acid promoting neutrophil chemotaxis
Gut microbiota dysbiosis and immune dysregulation are closely linked to colorectal cancer development. Identifying mechanistic connections among specific microbial species, metabolites, and immune responses may reveal novel insights into its pathogenesis. Here, employing metagenomic, metabolomic, an...
2026-05-20 | MTBLS14505 | MetaboLights
MetabolomicsRepair-Associated Macrophages Increase after Early-phase Microglia Attenuation to Promote Ischemic Stroke Recovery

Ischemic stroke recovery involves dynamic interactions between the central nervous system and infiltrating immune cells. Peripheral immune cells compete with resident microglia for spatial niches in the brain, but how modulating this balance affects recovery remains unclear. Here, we use PLX5622 ...

2025-02-20 | MTBLS12240 | MetaboLights
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