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ProteomicsMouse kidney glomeruli. Control vs. podocin(R231Q/A268V)
Similar to human patients, mice with the compound heterozygous mutation podocin R231Q/A268V, develop a late onset FSGS. Here, we did a proteomics anaylsis of kidney glomeruli before the onset of disease (mice at 3 weeks of age). Analysis of the data reveals that there are no developmental changes in...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-15 | PXD018326 | Pride
Podocin Glomerulus Kidney Nphs2 
ProteomicsMechanisms of pathogenic podocin in Nephrotic Syndrome reveal discrete trafficking and degradation Pathways
Nephrotic syndrome is a severe disease that significantly impairs kidney function, potentially leading to renal failure and a high mortality rate. Recent studies have shown that mutations in the kidney-specific protein Podocin are closely associated with the onset of this disease, with the R138Q-Pod...
ORGANISM(S): Homo Sapiens 
2025-02-17 | PXD060896 |
ProteomicsMapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot process.
The unique architecture of glomerular podocytes is integral to kidney filtration. Interdigitating foot processes extend from the podocyte cell body, wrap around fenestrated capillaries, and form specialized junctional complexes termed slit diaphragms to create a molecular sieve. However, the full co...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-17 | PXD042301 | Pride
Aging Ildr2 Fnbp1l Podocytes Bioid proximity labeling Foot process 
ProteomicsMapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot process.
The unique architecture of glomerular podocytes is integral to kidney filtration. Interdigitating foot processes extend from the podocyte cell body, wrap around fenestrated capillaries, and form specialized junctional complexes termed slit diaphragms to create a molecular sieve. However, the full co...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-23 | PXD042302 | Pride
Aging Ildr2 Fnbp1l Podocytes Bioid proximity labeling Foot process 
UnknownNew perspectives on the renal slit diaphragm protein podocin.
Not available
S-EPMC3182839 | biostudies-literature
ProteomicsDevelopment of a multiplexed LCMS assay for the quantitation of podocyte injury biomarkers nephrin, podocalyxin, and podocin in human urine
Targeted peptide immunoaffinity LCMS was conducted on clarified human urine using stable isotope labeled peptides for the absolute quantitation of nephrin, podocalyxin and podocin in samples from CKD patients and controls.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-28 | MSV000094428 | MassIVE
UnknownStructural features and oligomeric nature of human podocin domain.
Not available
S-EPMC7322680 | biostudies-literature
UnknownProteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury.
Not available
S-EPMC7681011 | biostudies-literature
UnknownIn vivo characterization of a podocyte-expressed short podocin isoform.
Not available
S-EPMC10731740 | biostudies-literature
UnknownThe ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
Not available
S-EPMC4787903 | biostudies-literature
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