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TranscriptomicsMRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers.
We have performed bioinformatic approaches to identify the level of enrichment between gene expression profiles characterizing MSI tumors and gene changes induced in vitro by the PARP-1 inhibitor Phenanthridinone and others using the Connectivity Map tool. In a first step, we have anyzed the express...
ORGANISM(S): Homo sapiens 
2011-04-07 | E-GEOD-26682 | biostudies-arrayexpress
TranscriptomicsRNA-seq from control and macroH2A1-depleted IMR90 primary human lung fibroblasts
The histone variant macroH2A1 and the poly(ADP-ribose) polymerase PARP-1 both regulate gene transcription by modulating chromatin structure and function. Of the two macroH2A1 splice variants, macroH2A1.1 and macroH2A1.2, the former is often suppressed in cancer and has the unique ability to interact...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-54846 | biostudies-arrayexpress
ProteomicsMultiple roles for PARP1 in ALC1-dependent nucleosome remodeling
XL-MS mass spectrometry analysis Cross-linked peptides were resolved for mass spectrometry analysis using a Dionex UltiMate 3000 RSLnano liquid chromatography system. Peptides were initially loaded from the autosampler onto an Acclaim PepMap 100 C18 LC Trap Cartridge (0.3 mm inside diameter, 5 mm le...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-10 | MSV000087174 | MassIVE
TranscriptomicsPoly(ADP-ribose) polymerase 3: a key regulator of ectodermal specification and neural crest development.
Poly(ADP-ribose) polymerase 3 (PARP3) is a member of the PARP family of enzymes. It is structurally related to the well characterized type member PARP1 that orchestrates DNA strand break repair and cell death by the synthesis of poly(ADP-ribose). In contrast, the functions of PARP3 are undefined. We...
ORGANISM(S): Homo sapiens 
2011-08-17 | E-GEOD-23709 | biostudies-arrayexpress
ProteomicsSystem-wide identification of enzyme substrates by thermal analysis (SIESTA)
Despite the immense importance of enzyme-substrate reactions, there is a lack of general and unbiased tools for identifying the molecular components participating in these reactions on a cellular level. Here we developed a universal method called System-wide Identification of Enzyme Substrates by Th...
ORGANISM(S): Homo sapiens (Human) 
2021-01-11 | PXD010554 | Pride
Poly-(adp-ribose) polymerase-10 Post-translational modification Target Thioredoxin reductase 1 Artd10 Thermal stability Trxr1 Parp10 Marylation Substrate 
TranscriptomicsNotch/HES1-mediated PARP1 activation: A cell-type specific mechanism for tumor suppression
Notch signaling plays both oncogenic and tumor suppressor roles, depending on cell type. In contrast to T cell acute lymphoblastic leukemia (T-ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B-ALL leads to growth arrest and apoptosis. The Notch target Hairy/Enha...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-26366 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model for Werner syndrome
Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. The poly(ADP-ribose) polymerase-1 (PARP-1) enzyme is also in...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3359 | biostudies-arrayexpress
UnknownGranzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure.
Not available
S-EPMC10399148 | biostudies-literature
UnknownPoly(ADP-Ribose) Polymerase Inhibitors in Pancreatic Cancer: A New Treatment Paradigms and Future Implications.
Not available
S-EPMC6966572 | biostudies-literature
UnknownInhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium.
Not available
S-EPMC4718819 | biostudies-literature
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