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ProteomicsMurine IgG (polyclonal) from Listeria Challenged pregnant dams
IgG was collected from virgin and pregnant listeria challenged mouse plasma. Polyclonal IgG was analyzed by reduction, alkylation, and LC-MS with top-down MS/MS (HCD and ETD)to look for glycosylation PTMs
ORGANISM(S): Mus musculus (Mouse) 
2022-06-28 | PXD033357 | Pride
Polyclonal Igg Listeria Murine Igg2 
TranscriptomicsGene expression profiling of persistent polyclonal B cell lymphocytosis PPBL and control IgMpos B cell subsets
To study the nature of persistent polyclonal B cell lymphocytosis (PPBL), we purified CD27posIgMposIgDpos from 4 patients, as well as transitional (CD38hiCD24hi), pre-naive (CD38dimCD24dimCD5pos), naive mature (CD38dimCD24dimCD5-CD27-), natural effector (CD27posIgMposIgDpos) and IgM-only (CD27posIgM...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-MEXP-3767 | biostudies-arrayexpress
ProteomicsTowards middle-up analysis of polyclonal antibodies: subclass-specific N-glycosylation profiling of murine immunoglobulin G (IgG) by means of HPLC-MS
Advanced analytical strategies including top-down and middle-up HPLC-MS approaches have become powerful alternatives to classical bottom-up analysis for the characterization of therapeutic monoclonal antibodies. Here, we assess feasibility of middle-up analysis of polyclonal IgGs posing additional c...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-26 | PXD014710 | Pride
Speb Phl p 6 vaccination Murine igg subclass quantification N-glycosylation 
GenomicsPolyclonal interactions overcome fitness barriers in Apc-driven intestinal tumorigenesis
Polyclonal interactions overcome fitness barriers in Apc-driven intestinal tumorigenesis
PRJNA1139121 | ENA
ProteomicsEpitope Mapping of Human Polyclonal Antibodies to the fHbp Antigen of a Neisseria Meningitidis Vaccine by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)
Antigen-antibody interactions play a key role in the immune response post vaccination and the mechanism of action of antibody-based biopharmaceuticals. 4CMenB is a multicomponent vaccine against Neisseria meningitidis serogroup B in which factor H binding protein (fHbp) is one of the key antigens. I...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD046572 | Pride
Polyclonal antibodies Pab Fhbp Hdx-ms 
GenomicsThymoSpheres culture: a model to study human polyclonal unconventional T cells
ThymoSpheres culture: a model to study human polyclonal unconventional T cells
PRJNA1122544 | ENA
TranscriptomicsTranscript profile comparison of Zbtb20-sufficient and Zbtb20-deficient polyclonal bone marrow plasma cells
ZBTB20 is an adjuvant-specific factor for long-term antibody responses. This factor is critical for maintaining long-lived plasma cells in alum-adjuvanted antibody responses but is dispensable for TLR ligand-adjuvanted responses. To identify the functions of ZBTB20 in long-lived plasma cells, we per...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-58659 | biostudies-arrayexpress
ProteomicsSynthetic polyclonal-derived CDR peptides as innovative strategy in glaucoma therapy
The pathogenesis of glaucoma is strongly associated with the occurrence of autoimmune-mediated loss of retinal ganglion cells (RGCs) and recently it was proven that specific antibody-derived signature peptides are significantly differentially expressed in sera of primary open angle glaucoma patients...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2019-08-15 | PXD014718 | Pride
Glaucoma  autoimmunity  synthetic cdr peptides  neuroprotection  htra2  sus scrofa domesticus 
ProteomicsIn vitro expanded and activated polyclonal γδ memory T cells for treatment of cancer
γδ-T lymphocytes are cells of the innate immune system exerting potent natural cytotoxicity against bacteria, viruses and tumours. This ability, coupled with their negligible alloreactivity, makes them attractive for adoptive immunotherapy approaches. To achieve a cell product suitable for clinical ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-18 | PXD015506 | Pride
Γδ t cells cancer 
ProteomicsMiddle-up analysis of polyclonal IgG-Fc
Middle-up strategy for the analysis of the fragment crystallizable (Fc) region of human plasma immunoglobulins G (IgGs). The use of hydrophilic interaction liquid chromatography (HILIC) and capillary electrophoresis (CE) coupled to mass spectrometry (MS) allowed to get a comprenhesive view of the N-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-08 | MSV000085388 | MassIVE
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