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To investigate the role of autophagy on cytotoxic CD8 T cells, we developed a new mouse that expresses an Atg5 gene with loxP sites up- and downstream of the exon 3, Cre-recombinase, T cell receptor specific for the OVA peptide SIINFEKL and the congenic marker Thy1.1. These cells were adoptively tra...
ORGANISM(S): Mus musculus 
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues fro...
ORGANISM(S): Homo sapiens 
We analyzed the molecular changes in a mouse c-MET over-expression model of hepatocellular carcinoma (HCC). FVB mice overexpressing human c-MET carried one copy of the LAP-tTa transgene (the liver-specific LAP promoter driving the Tet-VP16 transactivator) and one copy of the TRE-c-MET transgene (Tet...
ORGANISM(S): Mus musculus 
Expression profiles indicate that C-terminal of rep2 is essential for its transactivation activity. Keywords: rep2 mutants cells treated with 8 mM HU for different time points vs wildtype untreated cells We analyzed 40 arrays for rep2 mutants cells treated with 8 mM HU to wild type cells.
ORGANISM(S): Schizosaccharomyces pombe 
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