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MetabolomicsGlutamate-mediated metabolic rewiring boosts CpxA/R-OmpF porin and proton motive force to resensitize antibiotic-resistant Escherichia coli to ceftazidime

Ceftazidime (CAZ) is a critically important broad-spectrum antibiotic widely used in clinical practice. However, the rapid emergence of bacterial resistance to CAZ poses a significant challenge in treating infections caused by multidrug-resistant pathogens. In this study, we employed a metabolism...

2026-01-20 | MTBLS13732 | MetaboLights
ProteomicsProteomics profiling of major porin deficient Klebsiella pneumoniae in response to ertapenem treatment
The ertapenem-resistant K. pneumoniae strain 2018B120 with major porin loss was isolated from a clinical patient, comprehensive genomics and proteomics analysis were conducted.
ORGANISM(S): Klebsiella Pneumoniae Jh1 
2023-08-14 | PXD030432 |
ProteomicsInsights on the S-layer Deinoxanthin Binding Complex of Deinococcus radiodurans, a massive protein complex with a porin-like structure and function
In Deinococcus radiodurans the outermost Surface layer is tightly matched with the rest of the cell wall into a compact and integrated structure able to contrast environmental adversities. The fundamental unit of this S-layer is the S-layer Deinoxanthin Binding Complex, which has been reported to bi...
ORGANISM(S): Deinococcus radiodurans Bacteria 
2020-02-18 | PXD015568 | Pride
Porin S-layer Protein complex Deinococcus radiodurans 
TranscriptomicsSuperfolder GFP reporters validate diverse new mRNA targets of the classic porin regulator, MicF RNA
MicF is a textbook example of a small regulatory RNA (sRNA) that acts on a trans-encoded target mRNA through imperfect base paring. The discovery of MicF as a post-transcriptional repressor of the major Escherichia coli porin OmpF established the paradigm for a meanwhile common mechanism of translat...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2012-02-17 | E-GEOD-35848 | biostudies-arrayexpress
TranscriptomicsDeterminants of heat resistance in Escherichia coli AW1.7
Microarray hybridization of cDNA libraries obtained from exponentially growing or heat-shocked AW1.7 or GGG10 cultures was performed to compare gene expression of these two strains. Expression of selected genes from different functional groups was quantified by quantitative PCR (q-PCR). DnaK, 30S an...
ORGANISM(S): Escherichia coli 
2011-03-02 | E-GEOD-27607 | biostudies-arrayexpress
ProteomicsAcetylome reveals the lysine acetylation modifications on outer membrane protein Aha1 in Aeromonas hydrophila regulate the porin permeability to multidrug antibiotics
Acetylome reveals the lysine acetylation modifications on outer membrane protein Aha1 in Aeromonas hydrophila regulate the porin permeability to multidrug antibiotics
ORGANISM(S): Aeromonas Hydrophila Subsp. Hydrophila Atcc 7966 
PXD028447 |
ProteomicsAn outer membrane porin-lipoprotein complex modulates elongasome movement to establish cell curvature in Rhodospirillum rubrum
Curved cell shapes are widespread among bacteria and important for cellular motility, virulence and fit-ness. However, the underlying morphogenetic mechanisms are still incompletely understood. Here, we identify an outer-membrane protein complex that promotes cell curvature in the pho¬tosynthetic sp...
ORGANISM(S): Rhodospirillum rubrum 
2024-07-17 | PXD049473 | Pride
Peptidoglycan Bacteria Morphogenesis Cell wall Cell shape 
ProteomicsPorins from Corynebacterium glutamicum
Full proteoform characterization of recombinant porin A, porin B, porin C and porin H from Corynebacterium glutamicum
ORGANISM(S): Corynebacterium Glutamicum (ncbitaxon:1718) 
2017-02-02 | MSV000080529 | MassIVE
ProteomicsPorin expression in clinical isolates of Klebsiella pneumoniae: a comparison of SDS-PAGE and MALDI-TOF/MS and limitations of whole genome sequencing analysis Porin expression in clinical isolates of Klebsiella pneumoniae: a comparison of SDS-PAGE and MALDI-TOF/MS and limitations of whole genome sequencing analysis
Precise definition of porin profiles is of critical importance to understand the role of porins in antimicrobial resistance. In this study, the outer membrane proteins (OMP) profiles of 26 clinical isolates of Klebsiella pneumoniae and of strain ATCC 13883 (wild-type) and ATCC 700603 (producing SHV-...
ORGANISM(S): Klebsiella pneumoniae subsp. rhinoscleromatis ATCC 13884 Bacteria 
2025-05-07 | PXD053879 | Pride
Porins Klebsiella Lcms/ms 
Genomics
Generation of porin oculocutaneous albinism type 1 model
PRJNA1063373 | ENA
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