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ProteomicsQuantitative Single-Cell Proteomics as a Tool to Characterize Cellular Hierarchies
Large-scale single-cell analyses are of fundamental importance in order to capture biological heterogeneity within complex cell systems, but have largely been limited to RNA-based technologies. Here we present a comprehensive benchmarked experimental and computational workflow, which establishes glo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-21 | MSV000090570 | MassIVE
TranscriptomicsRetroviral insertional mutagenesis screen in a C/EBPalpha proliferative genetic background
The CCAAT enhancer binding protein alpha (C/EBPalpha) transcription factor plays a key role in the regulation of growth and differentiation of the granulocytic lineage in the hematopoietic system and CEBPA (encoding C/EBPalpha) is often mutated or deregulated in AML patients. Consistently, mice lack...
ORGANISM(S): Mus musculus 
2008-05-31 | E-GEOD-8032 | biostudies-arrayexpress
ProteomicsQuantitative Single-Cell Proteomics as a Tool to Characterize Cellular Hierarchies
Large-scale single-cell analyses are of fundamental importance in order to capture biological heterogeneity within complex cell systems, but have largely been limited to RNA-based technologies. Here we present a comprehensive benchmarked experimental and computational workflow, which establishes glo...
ORGANISM(S): Homo sapiens (Human) 
2021-05-06 | PXD020586 | Pride
Tmtpro Lc-ms Single cell proteomics Scms 
TranscriptomicsTranscription profiling of livers of adult UPF2 null mice in response to partial hepatechtomy
Deletion of the NMD component UPF2 in adult liver and response to partial hepatechtomy. Lethally irradiated Upf2flox/flox and Upf2flox/flox; Mx1Cre animals were transplanted with WT BM at 10-12 weeks of age. 5-6 following transplantion the bone marrow transplanted (BMT) animals were injected 3 times...
ORGANISM(S): Mus musculus 
2010-06-17 | E-MEXP-2249 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fetal livers of UPF2 null mice
Deletion of the NMD component UPF2 in fetal liver. Upf2flox/+ females were mated to Upf2flox/+; Alfp-Cre males. Fetal livers were isolated from Upf2+/+; Alfp-Cre (WT) and Upf2flox/flox; AlfpCre (UPF2 null) E16.5 and E18.5 embryos.
ORGANISM(S): Mus musculus 
2010-06-17 | E-MEXP-2248 | biostudies-arrayexpress
ProteomicsThe p30 isoform of CEBPA uncovers a silent enhancer to drive the expression of the tumor promoting factor CD73 in CEBPA mutant AML
The key myeloid transcription factor (TF) CEBPA is frequently mutated in acute myeloid leukemia (AML), but the molecular ramifications of this leukemic driver mutation remain elusive. To investigate CEBPA mutant AML, we compared gene expression changes in human CEBPA mutant AML and in the correspond...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-08 | PXD011359 | Pride
Cebpa Global proteomics Acute myeloid leukemia 
GenomicsAsxl1 and Cebpa cooperation in AML revealed by a novel Asxl1 mutant mouse model
Asxl1 and Cebpa cooperation in AML revealed by a novel Asxl1 mutant mouse model
PRJNA551034 | ENA
GenomicsAmplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq
ChIP-seq is used to map transcription factor occupancy and generate epigenetic profiles genome-wide. The requirement of nano-scale ChIP DNA for generation of sequencing libraries has impeded ChIP-seq on in vivo tissues of low cell numbers. We describe a robust, simple and scalable methodology for Ch...
ORGANISM(S): Mus musculus 
2015-02-01 | E-GEOD-55850 | biostudies-arrayexpress
UnknownRacial/Ethnic Disparities In COVID-19 Exposure Risk, Testing, And Cases At The Subcounty Level In California.
Not available
S-EPMC8458028 | biostudies-literature
GenomicsTemporal mapping of C/EBPα and –β binding during liver regeneration
Temporal mapping of C/EBPα and –β binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries. Timeseries ChIP-seq of transcription factors C/EBPα and –β, and Pol II in time points 0, 3, 8, 16, 24, 36, 48, 168 hours after pa...
ORGANISM(S): Mus musculus 
2013-01-24 | E-GEOD-42321 | biostudies-arrayexpress
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