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ProteomicsQuantifying Positional Isomers (QPI) by top-down mass spectrometry
Proteomics has exposed a plethora of post-translational modifications, but demonstrating functional relevance requires new approaches. Top-down proteomics can characterize co-occurring modifications in terms of localization, abundance and hierarchy. Here, we present a top-down MS analysis workflow f...
ORGANISM(S): Homo sapiens (Human) 
2021-03-18 | PXD012084 | Pride
Top-down mass spectrometry Positional isomers Quantitation Phosphorylation 
ProteomicsDual-Resolving of Positional and Geometric Isomerism of C=Cs via Bifunctional Visible-light-activated Photocycloaddition-Photoisomerization Reaction System
The biological functions of lipids largely depend on their chemicalspatial structures. The position and configuration of C=C bonds are two of the essential attributes that determine the structures of unsaturated lipids. However, simultaneous identification of both attributes remains challenging. Her...
ORGANISM(S): Homo Sapiens Arabidopsis Thaliana 
2022-02-19 | PXD031819 |
ProteomicsDIA dataset showing positional isomers.
DIA dataset showing positional isomers. MCF-7 cells were lysed, digested with trypsin, and phospho-enriched using IMAC Fe beads. DIA measurements were made from 500 to 1000 m/z using 20 m/z staggered windows. Sample prep and DIA measurements were acquired using the protocol described in Lawrence RT,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-14 | MSV000092156 | MassIVE
ProteomicsThesaurus: quantifying phosphopeptide positional isomers
Raw DIA/DDA data to support Thesaurus manuscript. The human phosphorylation regulatory network represents a complex signaling cascade where proteins can be phosphorylated at multiple sites resulting in different functional states. Here we present Thesaurus, a hybrid search engine that detects, local...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082956 | MassIVE
UnknownThesaurus: quantifying phosphopeptide positional isomers.
Not available
S-EPMC7012383 | biostudies-literature
UnknownPosition Matters: Fluorescent Positional Isomers for Reliable Multichannel Encryption Devices.
Not available
S-EPMC9298033 | biostudies-literature
UnknownQuantifying Positional Isomers (QPI) by Top-Down Mass Spectrometry.
Not available
S-EPMC8099777 | biostudies-literature
UnknownDifferentiating the aromatic positional isomers of methylbuphedrones and methoxybuphedrones via chemical ionization-mass spectrometry.
Not available
S-EPMC11142392 | biostudies-literature
UnknownDifferentiating Positional Isomers of Nucleoside Modifications by Higher-Energy Collisional Dissociation Mass Spectrometry (HCD MS).
Not available
S-EPMC6062210 | biostudies-literature
UnknownQuantitative determination of sn-positional phospholipid isomers in MSn using silver cationization.
Not available
S-EPMC9482905 | biostudies-literature
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