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ProteomicsThe NAE1-mediated Neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Cells were lysed with TFA, and precipitated with cold acetone. The precipitates were transferred to E3filters and digestion was performed overnight with trypsin. The peptides were desalted with StageTips, and were analyzed on Eclipse Orbitrap with DIA mode. For MS1, the resolution was set to 120,00...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-27 | MSV000094179 | MassIVE
ModelsSmith2010 - Response of FOXO Transcription Factors to Post-Translational Modifications (with acetylation pathway)
Graham R. Smith & Daryl P. Shanley. Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. PLoS ONE 5, 6 (2010). FOXO transcription factors are an important, conserved family of regulators of cellular processes i...
2024-09-02 | BIOMD0000000706 | BioModels
MetabolomicsPP2Cm Dysregulation Is Associated with Impaired BCAA Catabolism and cGAS-STING Activation in Diabetic Kidney Disease
Background and Aims:Branched-chain amino acids (BCAAs) are increasingly implicated in diabetic kidney disease (DKD), yet the role of protein phosphatase 2C mitochondrial (PP2Cm), encoded by PPM1K and regulating BCAA catabolism through the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, rema...
2026-10-09 | MTBLS15967 | MetaboLights
ModelsSmith2010 - Response of FOXO Transcription Factors to Post-Translational Modifications Made by Ageing-Related Signalling Pathways
Graham R. Smith & Daryl P. Shanley. Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. PLoS ONE 5, 6 (2010). FOXO transcription factors are an important, conserved family of regulators of cellular processes i...
2024-09-02 | BIOMD0000000705 | BioModels
ProteomicsCo-translational and Post-translational protein myristoylation in HeLa cells
Protein N-myristoylation is a ubiquitous co- and post-translational modification that has been implicated in the development and progression of a range of human diseases. In E. Thinon, R. A. Serwa, et al., Nature Communications 2014, doi:10.1038/ncomms5919, we report the global N-myristoylated prote...
ORGANISM(S): Homo sapiens (Human) 
2018-07-31 | PXD002687 | Pride
Co-translational modification Post-translational modification Apoptosis Protein myristoylation 
TranscriptomicsHow post-translational modification of nitrogenase is circumvented in Rhodopseudomonas palustris strains that produce hydrogen gas constitutively
Characterization of post-translational modification of nitrogenase in Rhodopseudomonas palustris strains that produce hydrogen gas constitutively. To characterize the effect of yeast extract as nitrogen source on gene expression under nitrogen fixing conditions, expression profiles of wild-type cell...
ORGANISM(S): Rhodopseudomonas palustris 
2012-03-15 | E-GEOD-32292 | biostudies-arrayexpress
ProteomicsIdentification of cGAS post-translational modifications
DNA derived from the genetic material of pathogens or from cellular DNA damage provides a molecular pattern that can be sensed by pattern-recognition receptors of the mammalian innate immune system. In recent years, the cyclic GMP-AMP synthase (cGAS) protein has been characterized as a primary cytos...
ORGANISM(S): Homo Sapiens 
2020-05-08 | PXD017133 | panorama
ModelsAhmedMobeen2021 - NF-kB Activation Model
NF-kappaB Activation Model includes the activation of both NFKB1:RELA and NFKB2:RELB for Canonical and Non-Canonical Pathway respectively. The model includes the pathway model integrated with post-translational modifications of NF-kB subunits that regulate the NFKB1:RELA and NFKB2:RELB activity. The...
2022-05-27 | MODEL2001290001 | BioModels
ProteomicsCharacterisation of protein methyltransferases Rkm1, Rkm4, Efm4, Efm7, Set5 and Hmt1 reveals extensive post-translational modification
Protein methylation is one of the major post-translational modifications (PTMs) in the cell. In Saccharomyces cerevisiae, over twenty protein methyltransferases (MTases) and their respective substrates have been identified. However, the way in which these MTases are modified, and potentially subject...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-12-18 | PXD006767 | Pride
Metyltransferases Post-translational modifications Rkm1 Hmt1 Efm7 Rkm4 Set5 Efm4 
ProteomicsArabidopsis thaliana PTM dynamics during dark-light transition
Two proteomics DDA experiments investigating dynamics of post-translational modifications in Arabidopsis thaliana whole leaf rosettes at multiple harvest times around dark to light transition. One experiment regarding acetylation (K) and phosphorylation (STY) after serial enrichment of dimethyl labe...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
PXD041832 | JPOST Repository
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