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MetabolomicsPP2Cm Dysregulation Is Associated with Impaired BCAA Catabolism and cGAS-STING Activation in Diabetic Kidney Disease
Background and Aims:Branched-chain amino acids (BCAAs) are increasingly implicated in diabetic kidney disease (DKD), yet the role of protein phosphatase 2C mitochondrial (PP2Cm), encoded by PPM1K and regulating BCAA catabolism through the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, rema...
2026-10-09 | MTBLS15967 | MetaboLights
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
TranscriptomicsTranscription profiling by array of human peripheral blood gamma-delta T cells stimulated with HMB-PP or OKT-3
Here we compare the transcriptional profile of HMB-PP-stimulated versus OKT-3 stimulated human peripheral blood gamma-delta T cells. We show that HMB-PP faithfully reproduces the transcriptional events associated with bona fide activation through the T cell receptor (TCR).
ORGANISM(S): Homo sapiens 
2008-09-01 | E-MEXP-1601 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression profile in persimmon peel extract administrated GK rat
Persimmon (Diospyros kaki L. f.) is a most popular fruit in Asian countries but its peels are totally wasted despite of containing a plenty of antioxidants such as carotenoids and polyphenols. We prepared a fat-soluble extract from a persimmon peel (PP) fraction and fed type 2 diabetic Goto-Kakizak...
ORGANISM(S): Rattus norvegicus 
2011-03-17 | E-GEOD-21417 | biostudies-arrayexpress
TranscriptomicsEffect of LOX-PP on the gene expression profile of the A673 cell line (Ewing sarcoma)
In this study we show that lysyl oxidase (LOX), an enzyme involved in maintaining structural integrity of the extracellular matrix, is expressed at low levels in Ewing sarcoma cells and primary tumors and is downregulated by the EWS/FLI1 oncoprotein characteristic of these tumors. Using a doxycyclin...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-46407 | biostudies-arrayexpress
TranscriptomicsRole of pp-ips in rpd3 complex and the environmental stress response (ESR)
Cells respond to stress and starvation by adjusting their growth rate and enacting stress defense programs. In eukaryotes this involves inactivation of TORC1, which in turn triggers downregulation of ribosome and protein synthesis genes and upregulation of stress response genes. Here we report that ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-22 | GSE45370 | GEO
TranscriptomicsRole of pp-ips in rpd3 complex and the environmental stress response (ESR)
Cells respond to stress and starvation by adjusting their growth rate and enacting stress defense programs. In eukaryotes this involves inactivation of TORC1, which in turn triggers downregulation of ribosome and protein synthesis genes and upregulation of stress response genes. Here we report tha...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-22 | E-GEOD-45370 | biostudies-arrayexpress
TranscriptomicsBacillus subtilis 168 cells: wild-type vs. (ccpN-yqfL) double mutant
Global transcriptional profiling of Bacillus subtilis cells comparing wild-type to a (ccpN-yqfL) double mutant. Abstract of the associated publication (article accepted): The transcriptional regulator CcpN of Bacillus subtilis has been recently characterized as a repressor of two gluconeogenic gen...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2008-07-01 | E-GEOD-11876 | biostudies-arrayexpress
TranscriptomicsBacillus subtilis 168 cells: wild-type vs. ccpN (non polar)
Global transcriptional profiling of Bacillus subtilis cells comparing wild-type to a ccpN (yqzB) non polar mutant. Abstract of associated publication (article accepted): The transcriptional regulator CcpN of Bacillus subtilis has been recently characterized as a repressor of two gluconeogenic genes...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2008-06-26 | E-GEOD-11873 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Y79 retinoblastoma cells upon Lysyl oxidase propeptide (LOX-PP) overexpression
Lysyl oxidase (LOX) is an copper dependent amine oxidase enzyme involved in cross linking of collagens and elastins. Lysyl oxidase propeptide (LOX-PP) is 18 kDa region cleaved during maturation of LOX and its anti-tumorigenic role were studied in various cancers. The effect of LOX-PP overexpression ...
ORGANISM(S): Homo sapiens 
2019-09-01 | GSE119413 | GEO
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