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TranscriptomicsExpression data from liver, PFC and amygdala of mice treated with PPAR agonists
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists have demonstrated therapeutic properties for several brain disorders, including alcohol depen...
ORGANISM(S): Mus musculus 
2015-04-14 | E-GEOD-67796 | biostudies-arrayexpress
ProteomicsFasting upregulates the monocarboxylate transporter Mct1 at the rat blood-brain barrier through Ppar d activation
Fasting is increasingly recognized as a potential therapeutic intervention in the field of neurology and psychiatry. However, its impact upon the blood-brain barrier (BBB), which strictly regulates the cerebral uptake of a wide range of endogenous compounds and drugs, is unknown. In this study we us...
ORGANISM(S): Cellular Organisms 
2024-08-15 | PXD044587 | JPOST Repository
TranscriptomicsImmunoregulatory actions of epithelial cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20621 | biostudies-arrayexpress
TranscriptomicsImmunoregulatory actions of T cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20523 | biostudies-arrayexpress
TranscriptomicsThe immunoregulatory effect of macrophage-specific PPAR gamma deficiency on experimental inflammatory bowel disease
Inflammatory bowel disease (IBD) is a condition characterized by severe intestinal inflammation and immune cell activation. The severity of the disease can be mitigated by compounds which activate peroxisome proliferator-activated receptor gamma (PPAR gamma), a receptor present widely in tissues in...
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-23421 | biostudies-arrayexpress
MetabolomicsMetabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse (NMR assay)
Regulation between the fed and fasted state in mammals is partially controlled by peroxisome proliferator activated receptor-alpha (PPAR-alpha). Expression of the receptor is high in liver, heart and skeletal muscle, but decreases with age. A combined 1H NMR spectroscopy and GC-MS metabolomic approa...
2018-10-11 | MTBLS261 | MetaboLights
TranscriptomicsTranscription profiling of human hepatoblastoma cell lines to identify potential peroxisome proliferator-activated receptor (PPAR) target genes
HepG2 tet-off hPPARs treated with ligands
ORGANISM(S): Homo sapiens 
2007-09-13 | E-GEOD-2699 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of fatty acid metabolism genes of liver tissue from wild-type and PPAR? (-/-) mice exposed to 2,4-dinitrotoluene (fatty acid)
2,4-dinitrotoluene (2,4-DNT), a nitroaromatic used in industrial and explosive manufacturing processes, is known to contaminate artillery ranges, demilitarization areas and munitions manufacturing facilities. Previous transcriptomic and lipidomic studies identified energy metabolism as a principle ...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-50168 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of first molar tooth germ in PPAR-alpha knock-out and wild type mice
Embryologically the tooth is derived from both the ectoderm and neural crest (ectomesenchyme). It is often used as a model to study how epithelial–mesenchymal interactions can control differentiation and morphogenesis. During early development organs of ectodermal origin share both a set of signalli...
ORGANISM(S): Mus musculus 
2009-08-06 | E-MTAB-42 | biostudies-arrayexpress
GenomicsGenome-wide profiling of PPAR?:RXR and RNA polymerase II
Genome-wide profiling of PPAR?:RXR and RNA polymerase II reveals temporal activation of distinct metabolic pathways in RXR dimer composition during adipogenesis. Chromatin immunoprecipitation combined with deep sequencing was performed to generate genome-wide maps of peroxisome prolifelator-activat...
ORGANISM(S): Mus musculus 
2008-12-10 | E-GEOD-13511 | biostudies-arrayexpress
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