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ProteomicsSubstrate spectrum of PPM1D in the cellular response to DNA double strand breaks
PPM1D (also known as WIP1) is a p53-regulated protein phosphatase that modulates the DNA damage response (DDR) by dephosphorylation of DDR proteins. Amplification of PPM1D gene or gain-of-function mutations are commonly found in cancer. Here, we employed chemical inhibition of PPM1D and quantitative...
ORGANISM(S): Homo sapiens (Human) 
2022-09-06 | PXD035420 | Pride
Double strand breaks Atm Wip1 Kanadaptin Ppm1d Dna damage 
ProteomicsPhosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA repair at damaged telomeres
Protein phosphatase magnesium-dependent 1 delta (PPM1D) is involved in termination of the cell cycle checkpoint by counteracting activity of the tumour suppressor protein p53. By dephosphorylating various proteins at chromatin, PPM1D contributes to the control of DNA damage response and DNA repair. ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035268 | Pride
Trf2 Dna repair Ppm1d Dna damage response 
UnknownAllosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.
Not available
S-EPMC9246869 | biostudies-literature
UnknownCrystal structure and mechanistic studies of the PPM1D serine/threonine phosphatase catalytic domain.
Not available
S-EPMC11342775 | biostudies-literature
UnknownOptimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
Not available
S-EPMC3508689 | biostudies-literature
GenomicsGain-of-function PPM1D mutations attenuate ischemic stroke
Gain-of-function PPM1D mutations attenuate ischemic stroke
PRJNA1252735 | ENA
ProteomicsAllosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
Detailed characterization of PPM1D phosphatase by HDX-MS: conformational dynamics of the pathogenic truncated form (1-420) found in various cancers, the effect of different truncations and mutations and mapping an inhibitor binding site.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-20 | MSV000088711 | MassIVE
UnknownIdentification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy.
Not available
S-EPMC5090708 | biostudies-literature
UnknownDNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase.
Not available
S-EPMC3616712 | biostudies-literature
UnknownProtein Phosphatase Magnesium-Dependent 1δ (PPM1D) Expression as a Prognostic Marker in Adult Supratentorial Diffuse Astrocytic and Oligodendroglial Tumors.
Not available
S-EPMC5859240 | biostudies-literature
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