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ProteomicsPPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors. An siRNA screen of all protein phosphatases revealed that a poorly studied protein phosphatase, PPM1H, counteracts...
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD014794 | Pride
Lrrk2 Phosphatase Parkinson's disease Rab10 
ProteomicsStructural basis for the specificity of PPM1H phosphatase for Rab GTPases
LRRK2 serine/threonine kinase is associated with inherited Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their switch 2 motif to control their interactions with effectors. Recent work has shown that the metal-dependent protein phosphatase PPM1H counteracts LRRK2 by dephosp...
ORGANISM(S): Homo sapiens (Human) 
2021-08-11 | PXD026367 | Pride
Rab8a Ppm1h Dsbu crosslinking 
UnknownEnd-product inhibition of the LRRK2-counteracting PPM1H phosphatase.
Not available
S-EPMC12132568 | biostudies-literature
UnknownPPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.
Not available
S-EPMC6850886 | biostudies-literature
UnknownStructural basis for the specificity of PPM1H phosphatase for Rab GTPases.
Not available
S-EPMC8567228 | biostudies-literature
UnknownSpecific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H.
Not available
S-EPMC4042171 | biostudies-literature
UnknownLocalization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.
Not available
S-EPMC10622911 | biostudies-literature
UnknownPPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit progression of hepatocellular carcinoma.
Not available
S-EPMC10345229 | biostudies-literature
UnknownLow tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts.
Not available
S-EPMC6734651 | biostudies-literature
UnknownRegulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.
Not available
S-EPMC10304398 | biostudies-literature
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