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UnknownCytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.
Not available
S-EPMC3900248 | biostudies-literature
TranscriptomicsKRAS-Dependent Sorting of miRNAs and other small RNAs to secreted vesicles
Although long thought to act cell autonomously, mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. We have previously shown that mutant KRAS induces EGFR-ligand trafficking to exosomes and drastically alters exosomal protein contents,...
ORGANISM(S): Homo sapiens 
2015-08-28 | E-GEOD-67004 | biostudies-arrayexpress
UnknownRenal secretion of hydrochlorothiazide involves organic anion transporter 1/3, organic cation transporter 2, and multidrug and toxin extrusion protein 2-K.
Not available
S-EPMC6843032 | biostudies-literature
MetabolomicsMetabolomic fingerprinting of bull spermatozoa for identification of fertility signature metabolites
The objective of the study was to identify the fertility-associated metabolites in bovine spermatozoa using liquid chromatography-mass spectrometry (LC-MS). Six Holstein Friesian crossbred bulls (three high-fertile and three low-fertile bulls) were the experimental animals. Sperm proteins were isola...
2021-12-07 | MTBLS1071 | MetaboLights
UnknownCytochrome P450 Family 4F2 and 4F11 Haplotype Mapping and Association with Hepatic Gene Expression and Vitamin K Hydroxylation Activity.
Not available
S-EPMC10928895 | biostudies-literature
ProteomicsNeuroproteomics with Systems Biology: The proteomic landscape of adult human hypothalamus
The hypothalamus is an anatomically small, but functionally crucial region of the human brain. Normal hypothalamus functioning is central to the regulation of neuroendocrine and neurovegetative systems as well as modulation of chronobiology and behavioral aspects of the human body. Till date the hum...
ORGANISM(S): Homo sapiens (Human) 
2021-11-01 | PXD026879 | Pride
Hypothalamus Autophagy Proteomics Proteogenomics Post translational modifications Neuropeptides. Human brain Adult neurogenesis Orbitrap fusion 
UnknownOccurrence of overlooked zoonotic tuberculosis: detection of Mycobacterium bovis in human cerebrospinal fluid.
Not available
S-EPMC1448613 | biostudies-literature
ProteomicsA proteomic map of SUP-T1 cells
CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of different immune cells. They are known to play crucial roles in antibody class switching in B cells, neutrophil recruitment and activation of macrophages and CD8+ cytotoxic T cells. ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021272 | Pride
Mass spectrometry Cd4+ t helper cells T lymphocytes Label-free quantitation Systems biology Adaptive immunity 
ProteomicsA proteomic map of resting and activated CD4+ T cells
CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of different immune cells. They are known to play crucial roles in antibody class switching in B cells, neutrophil recruitment and activation of macrophages and CD8+ cytotoxic T cells. ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-18 | PXD021250 | Pride
Mass spectrometry Cd4+ t helper cells T lymphocytes Label-free quantitation Systems biology Adaptive immunity 
ProteomicsMps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation
Spindle assembly checkpoint (SAC) regulators such as the Mps1 kinase not only delay anaphase onset, but also correct improper chromosome-spindle linkages that would otherwise lead to missegregation and aneuploidy. However, the substrates and mechanisms involved in this pathway of error correction re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006135 | Pride
Proteomics Mps1 Chemical genetics Ska complex Spindle assembly checkpoint (sac) Pp2a-b56 
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