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ProteomicsPotent anti-SARS-CoV-2 activity by the natural product gallinamide A and analogues via inhibition of cathepsin L
The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a key host cysteine protease utilized b...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027300 | Pride
Mrc5 Sars-cov-2 Covid Cathepsin l Veroe6 Gallinamide a Hek293 
UnknownIntra- and inter-session reliability and repeatability of 1H magnetic resonance spectroscopy for determining total creatine concentrations in multiple brain regions.
Not available
S-EPMC11868024 | biostudies-literature
UnknownDominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response.
Not available
S-EPMC6729303 | biostudies-literature
MetabolomicsIntegrated Exposomics/Metabolomics for Rapid Exposure and Effect Analyses

The totality of environmental exposures and lifestyle factors, commonly referred to as the exposome, are poorly understood. Measuring the myriad of chemicals that humans are exposed to is immensely challenging and identifying disrupted metabolic pathways is even more complex. Here, we present a n...

2023-10-26 | MTBLS4556 | MetaboLights
UnknownBuprenorphine/Naloxone and methadone effects on laboratory indices of liver health: a randomized trial.
Not available
S-EPMC3543467 | biostudies-literature
UnknownInteraction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.
Not available
S-EPMC6724838 | biostudies-literature
UnknownStrenuous Exercise Alters Brain Creatine and Glutamate/Glutamine (Glx) in Humans: Evidence From Dynamic <sup>1</sup>H-MRS and <sup>1</sup>H-MRSI.
Not available
S-EPMC12829524 | biostudies-literature
UnknownPeptide secondary structure modulates single-walled carbon nanotube fluorescence as a chaperone sensor for nitroaromatics.
Not available
S-EPMC3102399 | biostudies-literature
UnknownCrystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle.
Not available
S-EPMC2525797 | biostudies-literature
UnknownComplexity in clinical diagnoses of acute exacerbation of chronic obstructive pulmonary disease.
Not available
S-EPMC10426055 | biostudies-literature
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