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ProteomicsInteractors of trapped protein from mitochondria from HeLa cells with stalled import TMT-MS
This study explores the consequences of import failure in mammalian cells; wherein, blocking the import machinery has profound effects on mitochondrial ultra-structure and dynamics, but, surprisingly, does not impact import. The explanation is an astonishing response involving intercellular mitochon...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD040098 | Pride
Mitochondria Hela Import Galactose 
UnknownROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
Not available
S-EPMC6363466 | biostudies-literature
UnknownThe PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells.
Not available
S-EPMC6694185 | biostudies-literature
UnknownPresequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number.
Not available
S-EPMC4816344 | biostudies-literature
ProteomicsMPP profiling in yeast - Quantitative profiling for substrates of the mitochondrial presequence processing protease reveals a set of non-substrate proteins increased upon proteotoxic stress
The majority of mitochondrial preproteins is targeted via N-terminal presequences that are cleaved upon import into the organelle. The essential mitochondrial processing protease (MPP) is assumed to cleave the majority of incoming precursors. However, only few substrate proteins of MPP have been exp...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-10-14 | PXD002063 | Pride
Mitochondrial processing protease mpp Mitochondria Chafradic Mitochondrial stress response Presequence import pathway 
OtherPrinciples of cotranslational mitochondrial protein import revealed by selective ribosome profiling
The biogenesis of nearly all mitochondrial proteins begins with translation on cytosolic ribosomes. How these proteins are subsequently delivered to mitochondria remains poorly understood. Here, we systematically investigated the coupling of mitochondrial protein translation and import using selecti...
ORGANISM(S): Homo sapiens 
2025-08-01 | GSE255657 | GEO
UnknownPresequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix.
Not available
S-EPMC4135617 | biostudies-literature
GenomicsPrinciples of cotranslational mitochondrial protein import revealed by selective ribosome profiling
Principles of cotranslational mitochondrial protein import revealed by selective ribosome profiling
PRJNA1076084 | ENA
UnknownNovel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.
Not available
S-EPMC11870511 | biostudies-literature
UnknownPrinciples of cotranslational mitochondrial protein import.
Not available
S-EPMC12396113 | biostudies-literature
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