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The function of the nervous system relies on tightly regulated, yet plastic synaptic vesicle release machinery at the presynaptic active zone. In Drosophila, a form of presynaptic active zone plasticity, Presynaptic Scaling, or PreScale, is executed by the ELKS-family scaffold protein Bruchpilot (BR...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-06-09 | PXD067034 | Pride
Homeostatic plasticity in the retina has been demonstrated using an established mouse model of Retinitis Pigmentosa caused by the P23H mutation in rhodopsin. While signaling between the sensory rod photoreceptors and rod bipolar cells is potentiated in the P23H/Gnat2-/- mice, the molecular mechanism...
ORGANISM(S): Mus Musculus 
2025-12-08 | PXD060180 | panorama
Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate pote...
ORGANISM(S): Rattus norvegicus 
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