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ProteomicsMass spec analysis of primary human erythroid cultures (healthy or thalassemic and treated or untreated with Decitabine)
Reactivation of gamma-globin is considered a promising approach for the treatment of beta-thalassaemia and sickle cell disease. Therapeutic induction of gamma-globin expression is fraught with lack of suitable therapeutic targets. In order to identify new potential targets we analysed the changes in...
ORGANISM(S): Homo sapiens (Human) 
2020-01-23 | PXD006889 | Pride
Human Decitabine Hbf Lc-ms Primary erythroid cultures 
TranscriptomicsHuman Erythroid Day 10 ChIP using GATA, PolII, H3 and H4
A large-scale analysis of histone acetylation as well as RNA polymerase II and GATA 1 interactions on chromosome 6q in human erythroid progenitor cells. Human erythroid progenitors from day 10 erythroid cultures were used for ChIP-chip analysis. For this purpose, the NimbleGen array system was used,...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-16541 | biostudies-arrayexpress
TranscriptomicsGene expression in primary erythroid cells and in bone marrow stromal cells following treatment with Sotatercept (ACE-011)
Gene expression in primary erythroid cells and in bone marrow stromal cells following treatment with Sotatercept (ACE-011) Gene expression profiles of erythroid cells derived from human CD34+ cells generated under standard conditions and in cultures containing conditioned media from bone marrow stro...
ORGANISM(S): Homo sapiens 
2012-10-20 | E-GEOD-41708 | biostudies-arrayexpress
TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
TranscriptomicsSynergism between PPAR? and glucocorticoid receptor signaling promotes self-renewal of BFU-E erythroid progenitors and increases red cell production [RNA-seq]
Analyses of gene expression by RNA-Seq in mouse E14.5 fetal liver burst-forming unit erythroid (BFU-E) cells untreated or treated by dexamethasone (DEX) with or without PPAR? agonist GW7647. RNA-Seq was performed on enriched populations of mouse BFU-E isolated from E14.5 fetal liver, as well as BFU-...
ORGANISM(S): Mus musculus 
2015-06-08 | E-GEOD-63836 | biostudies-arrayexpress
TranscriptomicsIdentification of genes regulated by glucocorticoids and an RNA binding protein (RBP) in early erythroid progenitor using microarray experiment
Early erythroid progenitors were isolated from mouse E14.5 fetal liver, infected with viruses encoding either control shRNA or shRNAs targeting the RNA binding protein (RBP), and cultured in a medium containing stem cell factor, erythropoietin, and insulin-like growth factor 1, in the absence or pre...
ORGANISM(S): Mus musculus 
2013-06-14 | E-GEOD-46215 | biostudies-arrayexpress
TranscriptomicsCUT&RUN profiling of BACH2, NRF2, and NFE2 in human primary CD34⁺ hematopoietic stem/progenitor cells and day-8 erythroid cells under wild-type and BACH2 knockdown conditions
CUT&RUN was performed to profile BACH2, NRF2, and NFE2 occupancy in human primary CD34⁺ hematopoietic stem and progenitor cells (day 0) and erythroid cells differentiated from CD34⁺ HSPCs (day 8). Experiments were conducted under wild-type, scrambled control, and BACH2 shRNA knockdown conditions to ...
ORGANISM(S): Homo sapiens 
2026-09-02 | E-MTAB-16108 | biostudies-arrayexpress
TranscriptomicsDevelopmental transcriptome analysis of human erythropoiesis
We profiled the dynamic, comprehensive transcriptome during human erythroid differentiation in vitro. The erythroid cells at day 4, 8, 11 and 14 differentiation stages were harvested and sequenced by Illumia 72 bp paired-end sequencing format, respectively. Expression profiling of erythroid cells on...
ORGANISM(S): Homo sapiens 
2014-05-05 | E-GEOD-54602 | biostudies-arrayexpress
TranscriptomicsTranscriptome of mouse erythroid cells (part1) poly(A)+
We report genome-wide maps of transcription in mouse erythroid cells. We used an approach to survey poly(A)+ (mRNA) (GSE26877) and non-polyadenylated RNA poly(A)- (GSE27920) separately. This provides an alternative framework for comprehensive transcriptome profiling in mammalian cells. Two Samples. ...
ORGANISM(S): Mus musculus 
2012-01-30 | E-GEOD-26877 | biostudies-arrayexpress
GenomicsSynergism between PPARα and glucocorticoid receptor signaling promotes self-renewal of BFU-E erythroid progenitors and increases red cell production [ChIP-seq]
ChIP-Seq analyses of GR and PPARa occupancy in mouse E14.5 fetal liver BFU-E cells untreated or treated by DEX with or without GW7647 ChIP-Seq on GR and PPAR alpha in purified 10^7 mouse BFU-E cells purified from E14.5 fetal livers with or without treatment of Dexamethasone and/or GW7647
ORGANISM(S): Mus musculus 
2015-06-08 | E-GEOD-62788 | biostudies-arrayexpress
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