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TranscriptomicsFunctional diversity and convergence of small non-coding RNAs in male germ cell differentiation and fertilization (mRNA analysis)
The small non-coding RNAs (sncRNAs) are considered as postranscriptional key regulators of male germ cell development. In addition to microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), other sncRNAs generated from small nucleolar RNAs (snoRNAs), tRNAs or rRNAs processing may also play important ...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-59252 | biostudies-arrayexpress
ProteomicsChicken embryonic stem cell/primordial germ cell LC-MSMS
As germ cell precursor, primordial germ cells (PGCs) are widely used in transgenic animal production, regenerative medicine and other fields. However, the regulation mechanism of chicken PGCs is not incomplete, which leads to the insufficient amount of chicken PGCs obtained in vitro, which seriously...
ORGANISM(S): Gallus gallus (Chicken) 
2025-09-08 | PXD052543 | Pride
Lc-msms Primordial germ cell Embryonic stem cell Chicken 
TranscriptomicsIdentification of genes specific to mouse primordial germ cells through dynamic global gene expression
The molecular mechanisms underlying the commitment of cells to the germ cell lineage and the subsequent formation of germ cells during mammalian development remain poorly understood due to an inability to obtain sufficient amounts of cellular materials to conduct thorough in-vitro analyses. Although...
ORGANISM(S): Mus musculus 
2010-11-16 | E-GEOD-23322 | biostudies-arrayexpress
TranscriptomicsOffspring from oocytes derived from in vitro primordial germ cell-like cells in mice
Reconstitution of female germ-cell development in vitro is a key challenge in reproductive biology and medicine. We show here that female (XX) embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) in mice are induced into primordial germ cell-like cells (PGCLCs), which, when aggrega...
ORGANISM(S): Mus musculus 
2012-11-05 | E-GEOD-40716 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Transgenerational Epigenetic Reprogramming of Primordial Germ Cells and Subsequent Germline
A number of environmental factors (e.g. toxicants) have been shown to promote the epigenetic transgenerational inheritance of disease and phenotypic variation. Transgenerational inheritance requires the germline transmission of altered epigenetic information between generations in the absence of dir...
ORGANISM(S): Rattus norvegicus 
2013-01-17 | E-GEOD-43559 | biostudies-arrayexpress
ProteomicsMolecular sexual identity of chicken in vitro derived pre-gonadal primordial germ cells
In poultry, in vitro derived primordial germ cells (PGCs) represent an important tool for management of genetic resources. However, several studies have highlighted sexual differences exhibited by PGCs through in vitro steps, which may compromise their reproductive capacities. To understand this phe...
ORGANISM(S): Gallus gallus (Chicken) 
2021-11-03 | PXD022452 | Pride
Primordial germ cells Chicken Sex differentiation 
TranscriptomicsRole of Ror2 in primordial germ cell migration
Primordial germ cells (PGCs), the embryonic precursors of eggs and sperm, are a unique model for identifying and studying regulatory mechanisms in singly migrating cells. From their time of specification to eventual colonization of the gonad, mouse PGCs traverse through and interact with many differ...
ORGANISM(S): Mus musculus 
2014-08-08 | E-GEOD-60179 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse single cells from primordial germ cell lineage (E6.25-E8.25, wild type and Blimp1KO)
Specification of germ cell fate is fundamental in development. With a highly representative single-cell microarray and rigorous quantitative-PCR analysis, we defined the genome-wide transcription dynamics that create primordial germ cells (PGCs) from the epiblast, a process that exclusively segrega...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-11128 | biostudies-arrayexpress
TranscriptomicsGene-expression profile of human embryonic germ cells
Gene-expression profile of human embryonic germ cells (EGCs), primordial germ cells (PGCs), embryonal carcinoma cells (ECCs), pluripotent embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSCs)
ORGANISM(S): Homo sapiens 
2018-06-28 | E-MTAB-6851 | biostudies-arrayexpress
ProteomicsIdentification of Key Events and Regulatory Networks in the Formation Process of Primordial Germ Cell based on Proteomics
Studies have analyzed the regulation mechanism of primordial germ cell (PGC) formation at the transcriptional level, but few at the protein level, showing the mechanism analysis of PGC formation not systematic. We collected embryonic stem cells and PGC using a novel sampling strategy and performed l...
ORGANISM(S): Gallus gallus (Chicken) 
2025-09-08 | PXD035490 | Pride
Chicken、escs、pgcs lc-ms/ms、proteomics 
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