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ProteomicsTemporal phosphoproteomics reveals key regulators of procoagulant COAT platelet generation
The intracellular signaling generating and sustaining the procoagulant response of platelets from a common aggregatory phenotype upon simultaneous collagen and thrombin (COAT) stimulation is only partially elucidated. Here we described the phosphoproteome of aggregatory and procoagulant COAT platele...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD062271 | Pride
Phosphoproteome Procoagulant Temporal Platelets Coat 
ProteomicsBeyond envenomation: functional dissection of Podalia orsilochus venom uncovers a procoagulant protein and additional toxic activities
Envenomation by urticating caterpillars of the family Megalopygidae is an underestimated public health issue in South America, with Podalia orsilochus being the main species implicated in cases reported in northeastern Argentina. This study aimed to characterize the toxicological properties of its v...
ORGANISM(S): Megalopygidae sp. BOLD:AAA3544 
2026-03-30 | PXD074932 | Pride
Megalopygidae Procoagulant activity Toxins Hemolysis Losac Proteolytic enzymes 
UnknownProcoagulant platelet activation promotes venous thrombosis.
Not available
S-EPMC11662225 | biostudies-literature
ProteomicsStunted Procoagulant Remodelling in Montreal Platelet Syndrome Kindred with p.V1316M mutation
The Montreal Platelet Syndrome Kindred (MPS) with p.V1316M mutation (2B-VWDMPS) has been associated with chronic macrothrombocytopenia, spontaneous platelet clumping, and mucocutaneous and other bleeding which can be largely prevented by von Willebrand factor concentrate infusion. However, supplemen...
ORGANISM(S): Homo sapiens (Human) 
2023-08-22 | PXD035713 | Pride
Membrane ballooning Chloride channel clic1 2b-vwd Cytoskeletal and contractile proteins Actin Procoagulant membrane dynamics Tubulin Montreal platelet syndrome 
UnknownSmall-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity.
Not available
S-EPMC10139176 | biostudies-literature
GenomicsAntiphospholipid antibodies induce Proinflammatory and Procoagulant Pathways in Endothelial cells.
Antiphospholipid antibodies induce Proinflammatory and Procoagulant Pathways in Endothelial cells.
PRJNA600847 | ENA
UnknownProcoagulant extracellular vesicles in amniotic fluid.
Not available
S-EPMC6544525 | biostudies-literature
UnknownAquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis.
Not available
S-EPMC6012506 | biostudies-literature
TranscriptomicsExpression of the MET oncogene correlates with upregulation of coagulation factor XII and procoagulant disorders in colorectal cancer
Cancer patients often develop hemostasis disorders whose pathogenesis is poorly understood. Previous work in mouse models has shown that these disorders can be sustained by the MET oncogene by transcriptional upregulation of hemostasis genes. Here we investigated the correlation between the procoagu...
ORGANISM(S): Homo sapiens 
2022-12-30 | GSE52060 | GEO
UnknownNovel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response.
Not available
S-EPMC6635759 | biostudies-literature
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