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ProteomicsThe interactome of flavin adenine dinucleotide (FAD) with RNA-binding proteins
We explored the interactome of flavin adenine dinucleotide (FAD) and the matrix of UV-immobilised FAD bound more than 3,000 proteins from SW-620 lysate. GO enrichment analysis showed that about 600 RNA-binding proteins were bound to FAD beads and, surprisingly, more than 40 proteins showed clear dos...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD036953 | Pride
Pum-rna Photo-immobilisation Fad Competition pulldown 
ProteomicsKinobead profiling of PITCOINs1-3
Phosphatidylinositol 3-kinase type 2a (PI3KC2a) and related class II PI 3-kinase isoforms are of rising biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signalling, angiogenesis, and platelet morphology and function. Herein we report the developmen...
ORGANISM(S): Homo sapiens (Human) 
2022-08-24 | PXD032284 | Pride
Pulldowns Pi3kc2a Kinobeads 
ProteomicsDiazirine photo-immobilisation for target profiling of natural products and co-factors: pulldown data
Finding the targets of natural products is of key importance in both chemical biology and drug discovery, and deconvolution of cofactor interactomes contribute to the functional annotation of the proteome. Identifying the proteins that underlie natural compound activity in phenotypic screens help to...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-10-06 | PXD033292 | Pride
Photo-immobilisation Pulldowns Natural products profiling Natural products targets 
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