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ProteomicsProline hydroxylation of ChREBP
This project investigated proline hydroxylation of ChREBP. Proline hydroxylation was investigated in flag-IP enriched protein extracts from ChREBP-flag overexpressing HEK293 cells (A) and in ChREBP-IP enriched mouse liver protein (male, C57BL6/J) (B).
ORGANISM(S): Mus musculus (Mouse) 
2020-10-19 | PXD019137 | Pride
Hek293 Mouse liver Proline hydroxylation 
ProteomicsSystematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry (RCC4)
To improve understanding of the role of site-specific proline hydroxylation in controlling protein function, we have developed a robust workflow for the identification of proline hydroxylation sites in proteins using a combination of hydrophilic interaction chromatography (HILIC) enrichment and high...
ORGANISM(S): Homo sapiens (Human) 
2025-11-28 | PXD044783 | Pride
Hilic Proteomics Hydroxylation Mass spectrometry Proline 
ProteomicsSystematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry (HEK293)
To improve understanding of the role of site-specific proline hydroxylation in controlling protein function, we have developed a robust workflow for the identification of proline hydroxylation sites in proteins using a combination of hydrophilic interaction chromatography (HILIC) enrichment and high...
ORGANISM(S): Homo sapiens (Human) 
2025-11-28 | PXD044663 | Pride
Hilic Proteomics Hydroxylation Mass spectrometry Proline 
ProteomicsProlyl hydroxylation regulates protein degradation, synthesis and splicing in human induced pluripotent stem cell-derived cardiomyocytes
Protein hydroxylases are oxygen and alpha-ketoglutarate-dependent enzymes that catalyze hydroxylation of amino acids such as proline, thus linking oxygen and metabolism to enzymatic activity. Prolyl hydroxylation is a dynamic post-translational modification that regulates protein stability and prote...
ORGANISM(S): Homo sapiens (Human) 
2016-05-06 | PXD003621 | Pride
Lc-ms/ms Amino acid labeling Prolyl hydroxylation Ipsc-derived cardiomyocytes 
ProteomicsProteome-wide Investigation of Proline Hydroxylation in Pancreatic Ductal Adenocarcinoma Using DiLeu Isobaric Labeling Strategy
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer marked by a dense, collagen-rich extracellular matrix that promotes tumor progression. In this study, we developed a high-throughput method combining enhanced hydrophilic interaction chromatography (HILIC) and 12-plex N,N-dimethyl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095824 | MassIVE
GenomicsHistone H3 proline 16 hydroxylation regulates mammalian gene expression [RNA-Seq]
Histone H3 proline 16 hydroxylation regulates mammalian gene expression [RNA-Seq]
PRJNA742239 | ENA
ProteomicsProline hydroxylation of collagens in prolyl 4-hydroxylase mutant mice
Collagen from the skin of wild type and prolyl 4-hydroxylase mutant mice was extracted and proline hydroxylation of the collagen-derived peptides were analyzed by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2018-04-10 | PXD008802 | Pride
Mouse Collagen prolyl 4-hydroxylase 
GenomicsHistone H3 proline 16 hydroxylation regulates mammalian gene expression [CUT&RUN]
Histone H3 proline 16 hydroxylation regulates mammalian gene expression [CUT&RUN]
PRJNA742238 | ENA
ProteomicsProtein interactome analysis - Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation
The overall goal of the project was to identify proline hydroxylation dependent Brd4 interactome through label-free quantitative proteomics analysis.
ORGANISM(S): Homo sapiens (Human) 
2019-07-03 | PXD012633 | Pride
Brd4 Protein-protein interaction 
ProteomicsPHD3-mediated HIV-2 Vpx peptide hydroxylation
This dataset contains comparative mass spectrometry analysis investigating proline hydroxylation of synthetic HIV-2 Vpx peptides under two conditions: with and without PHD3 enzyme treatment. The analysis was performed using a high-resolution mass spectrometer coupled to a nano-LC system. The dataset...
ORGANISM(S): Human Immunodeficiency Virus 2 
2025-04-03 | PXD059242 | JPOST Repository
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