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MetabolomicsCoordinate Regulation of Metabolite Glycosylation and Stress Hormone Biosynthesis by TT8 in Arabidopsis
Secondary metabolites play a key role in coordinating ecology and defense strategies of plants. Diversity of these metabolites arise by conjugation of core structures with diverse chemical moieties, such as sugars in glycosylation. Active pools of phytohormones, including those involved in plant str...
2016-10-03 | MTBLS129 | MetaboLights
MetabolomicsZEB1 Maintains Energy Metabolism to Sustain Cardiac Function Through Synergistic Regulation with TEAD1
Metabolic reprogramming plays a critical role in heart failure (HF), but its regulatory mechanisms remain incompletely understood. Zinc finger E-box binding homeobox 1 (ZEB1), a transcription factor initially identified as a regulator of epithelial-mesenchymal transition, has recently been implicate...
2026-09-28 | MTBLS15833 | MetaboLights
MetabolomicsThe Lolal-dpp axis mediates the regulation of host reproduction by gut symbionts in insects

Gut commensal microbiota can play an integral role in shaping insect reproduction, but the mechanisms underlying this process remain largely unexplored. Here, we report that gut bacteria promote host reproduction in the oriental fruit fly Bactrocera dorsalis (Diptera: Tephritidae), an important a...

2025-11-05 | MTBLS13264 | MetaboLights
ProteomicsThe PURB-HOTAIR complex regulates p53-dependent promoter-specific transcriptional activation
p53 executes its diverse functions via different transcriptional targets, but the precise mechanism of promoter-specific regulation by p53 remains largely unknown. Through biochemical purification, we identify PURB, a dual DNA/RNA-binding protein, which acts as a transcriptional co-repressor for p53...
ORGANISM(S): Homo sapiens (Human) 
2025-04-24 | PXD042681 | Pride
Long non-coding rna Cis-regulatory element Epigenetics Promoter-specific regulation Hotair Suv39h1 Tumor suppression Purb P53 
ProteomicsACONITASE 3 is part of the ANAC017 transcription factor-dependent mitochondrial dysfunction response
Mitochondria are tightly embedded within metabolic and regulatory networks that optimize plant performance in response to environmental challenges. The best-known mitochondrial retrograde signaling pathway involves stress-induced activation of the transcription factor NAC DOMAIN CONTAINING PROTEIN 1...
ORGANISM(S): Arabidopsis Thaliana 
2022-03-14 | PXD018881 | panorama
TranscriptomicsTranscription profiling of Arabidopsis roots - transcriptional and posttranscriptional regulation of transcription factor expression
Understanding how the expression of transcription factor (TF) genes is modulated is essential for reconstructing gene regulatory networks. There is increasing evidence that sequences other than upstream noncoding can contribute to modulating gene expression, but how frequently they do so remains unc...
ORGANISM(S): Arabidopsis thaliana 
2009-06-23 | E-GEOD-16468 | biostudies-arrayexpress
GenomicsLineage-specific super-enhancer activates genes in a promoter-selective manner
Lineage-specific super-enhancer activates genes in a promoter-selective manner
PRJNA497314 | ENA
TranscriptomicsGenome-wide analysis reveals determinants of redundant and specific binding within a transcription factor family
A central question in transcription factor biology is how a specific member of a transcription factor family occupies a promoter in vivo, when all family members bind the same consensus site in vitro. To uncover the mechanisms regulating DNA binding specificity within transcription factor families,...
ORGANISM(S): Homo sapiens 
2007-07-27 | E-GEOD-7449 | biostudies-arrayexpress
TranscriptomicsRegulation of the microRNA processor DGCR8 by the tumor suppressor ING1
The ING familiy of tumor suppressor proteins control several cellular functions relevant to anti-tumor protection, like cell-cycle control, apoptosis, senescence or migration. ING proteins are functionally linked to the p53 pathway, and they participate in transcriptional control via the recognisit...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-18645 | biostudies-arrayexpress
TranscriptomicsExtensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped long-range chromatin interactions associated with RNA polymerase II in human cells and uncovere...
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-33664 | biostudies-arrayexpress
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