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ProteomicsChIRP-MS of long non-coding RNA HOTAIR
Accumulating evidence highlights the role of long non-coding RNAs (lncRNA) in cellular homeostasis, and their dysregulation in disease settings. Most lncRNAs function by interacting with proteins or protein complexes. While several orthogonal methods have been developed to identify these proteins, e...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD029057 | Pride
Lncrna Hotair Chirp-ms 
TranscriptomicsLong non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor positive primary breast cancer
Expression of HOX transcript antisense intergenic RNA (HOTAIR)—a long intergenic non-coding RNA (lincRNA)—has been examined in a variety of human cancers, and overexpression of HOTAIR is correlated with poor survival among breast, colon, and liver cancer patients. In this retrospective study, we exa...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-48408 | biostudies-arrayexpress
ProteomicsA ChIRP-MS analysis of HOTAIR in HeLa
We employed ChIRP in combination with proteomic strategy to systematically discover HOTAIR-interacting proteins. Three independent biological replicates of ChIRP-MS experiment were performed, alongside negative controls.
ORGANISM(S): Homo sapiens (Human) 
2021-07-09 | PXD015546 | Pride
Hotair hela chirp-ms 
TranscriptomicsThe long noncoding RNA HOTAIR has tissue and cell type dependent effects on HOX gene expression and phenotype of cancer cells
HOTAIR was found to be overepressed in a subset of urothelial cancer tissues and cell lines compared to normal controls. Ectopic HOTAIR expression in urothelial cancer cells in vitro demonstrated cell type dependent changes in phenotype. While some cell lines showed increased proloferation activity ...
ORGANISM(S): Homo sapiens 
2015-06-05 | E-GEOD-57672 | biostudies-arrayexpress
ProteomicsHOTAIR knockdown glioma cell proteomics
This study demonstrated the effects of lncRNA HOTAIR knockdown on the glioma proteomics. An abnormally high expression of the lncRNA HOTAIR has been previously demonstrated in glioma cells. HOTAIR regulates genes by anchoring epigenetic modification proteins and causes abnormalities in multiple sign...
ORGANISM(S): Homo Sapiens 
2021-12-31 | PXD029919 |
TranscriptomicsHOTAIR transfected Breast Cancer Cells
MDA-MB-231 Breast Cancer Cells were infected by retroviral expression with either VECTOR or HOTAIR. To test the role of polycomb in HOTAIR mediated gene expression, MDA-MB-231 HOTAIR cells were infected with short hairpin retroviral vectors targeting SUZ12 or EZH2. A genetic modification design typ...
ORGANISM(S): Homo sapiens 
2010-04-15 | E-GEOD-20435 | biostudies-arrayexpress
GenomicsTargeted disruption of Hotair leads to homeotic transformation and de-repression of imprinted genes [RNA-Seq, ChIP-Seq]
Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences of lncRNA inactivation in vivo are mostly unknown. Here we show that targeted deletion of mouse Hotair lncRNA leads to de-repression of hundreds of genes, resulting in homeotic transformatio...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-48005 | biostudies-arrayexpress
ProteomicsRNA-BioID of lncRNA HOTAIR in Flp-In T-REx cells
Accumulating evidence highlights the role of long non-coding RNAs (lncRNA) in cellular homeostasis, and their dysregulation in disease settings. Most lncRNAs function by interacting with proteins or protein complexes. While several orthogonal methods have been developed to identify these proteins, e...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD029058 | Pride
Lncrna Hotair Rna-bioid 
TranscriptomicsHOTAIR reprograms gene expression profiling in esophageal squamous cell carcinoma (ESCC) KYSE180 cells
To investigate the functional role of HOTAIR in esophageal squanmous cell carcinoma (ESCC) cells, RNAi-mediated knockdown of HOTAIR and overexpression of HOTAIR were carried out using KYSE180 cells. Gene expression microarray analysis revealed that a number of reported HOTAIR target genes were regul...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-47638 | biostudies-arrayexpress
ProteomicsHuman HepG2 ITRAQ LC-MS/MS - Integrated proteomic and transcriptomic analysis revealslong noncoding RNA HOTAIR promotes hepatocellular carcinoma cell proliferation by regulating opioid growth factor receptor (OGFr)
Long non-coding RNA HOX transcript antisense RNA (HOTAIR) is involved in human tumorigenesis and dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying HOTAIR functions in HCC are not well understood. Here, an integrated RNA sequencing transcriptomic and quantit...
ORGANISM(S): Homo sapiens (Human) 
2017-11-24 | PXD006554 | Pride
Hotair hcc lc-ms/ms itraq 
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