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TranscriptomicsIdentification of stromally expressed molecules in the prostate by Tag profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate
The stromal microenvironment plays key roles in prostate development and cancer. Cancer associated fibroblasts (CAFs) and other stromal cells stimulate tumourigenesis via several mechanisms including the expression of pro-tumourigenic factors. Mesenchyme (embryonic stroma) controls prostate organoge...
ORGANISM(S): Homo sapiens 
2011-10-22 | E-GEOD-25018 | biostudies-arrayexpress
TranscriptomicsComparison of Normal Prostate Fibroblasts Overexpressing Cyclin D1 and Carcinoma Associated Fibroblasts
The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-6936 | biostudies-arrayexpress
ProteomicsProteomics reveals the function reverse of MPSSS treated prostate cancer-associated fibroblasts to suppress PC-3 cell viability via the FoxO pathway
Prostate cancer (PCa) remains the malignancy with the highest morbidity in men (1). Although early-stage PCa usually causes no symptoms, cancer cells in prostate glands readily metastasize to bones, lymph nodes, lungs, and liver during PCa progression (2). Common strategies, including surgery, radia...
ORGANISM(S): Homo sapiens (Human) 
2021-03-22 | PXD023689 | Pride
Human Proteomics Prostate cafs Secretomics Prostate cancer cells Lc-ms/ms 
TranscriptomicsCells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations
Prostate cancer-associated stroma (CAS) plays an active role in malignant transformation, tumor progression, and metastasis. Molecular analyses of CAS have demonstrated significant changes in gene expression; however, conflicting evidence exists on whether genomic alterations in benign cells compris...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76456 | biostudies-arrayexpress
TranscriptomicsIntegrated miRNA and gene expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation [miRNA]
Tumor microenvironment coevolves with and simultaneously sustains cancer progression. Reactive fibroblasts found in prostate cancer (PCa), known as cancer associated fibroblasts (CAF), have been indeed shown to fuel tumor development and metastasis by mutually interacting with PCa cells. Little is k...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-68165 | biostudies-arrayexpress
TranscriptomicsIntegrated miRNA and gene expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation [gene]
Tumor microenvironment coevolves with and simultaneously sustains cancer progression. Reactive fibroblasts found in prostate cancer (PCa), known as cancer associated fibroblasts (CAF), have been indeed shown to fuel tumor development and metastasis by mutually interacting with PCa cells. Little is k...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-68164 | biostudies-arrayexpress
ProteomicsProteomic profiling of human prostate cancer-associated fibroblasts identifies LOXL2 promotes tumour migration in the extracellular matrix
In prostate cancer (PC), cancer-associated fibroblasts (CAFs) exhibit contrasting biological properties to non-malignant prostate fibroblasts (NPFs) and promote tumorigenesis. Resolving intercellular signaling pathways between CAFs and prostate tumor epithelium may offer novel opportunities for rese...
ORGANISM(S): Homo sapiens (Human) 
2019-05-24 | PXD010611 | Pride
Phosphoproteome Fibroblast Loxl2 Prostate cancer 
ProteomicsMast cell-derived SAMD14 is a novel regulator of the human prostate tumor microenvironment
Mast cells (MCs) are important cellular components of the tumor microenvironment and are significantly associated with poor patient outcomes in prostate cancer and other solid cancers. The promotion of tumor progression partly involves heterotypic interactions between MCs and cancer-associated fibro...
ORGANISM(S): Homo sapiens (Human) 
2021-03-12 | PXD022782 | Pride
Prostate cancer  tumor microenvironment  mast cells  samd14  cancer-associated fibroblasts  extracellular matrix 
GenomicsCancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients
Cancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients
PRJNA1124516 | ENA
ProteomicsHuman Prostate Cancer epithelial-fibroblast cell signalling by CTAP-MS
A greater understanding of cell signaling events that occur within the prostate cancer tumor microenvironment (TME), for example between cancer-associated fibroblasts (CAFs) and prostate epithelial or cancer cells, may identify novel biomarkers and more effective therapeutic strategies for this dise...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037272 | Pride
Ctap-ms Human Caf Prostate Fibroblast 
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