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MetabolomicsMetabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival

The spread of cancer to bone is invariably fatal, with complex cross-talk between tumor cells and the bone microenvironment responsible for driving disease progression. By combining in silico analysis of patient datasets with metabolomic profiling of prostate cancer cells cultured with bone cells...

2024-08-19 | MTBLS3973 | MetaboLights
TranscriptomicsTranscriptome of the bone metastasis associated stroma
The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance between osteoblast-mediated bone formation and...
ORGANISM(S): Mus musculus 
2014-12-09 | E-GEOD-22813 | biostudies-arrayexpress
ProteomicsIdentification of GDPP in cancer secretome
Prostate cancer cell lines were cultured with serum-free media, for 48 h. The cultured media were collected and lyophilized. The lyophilized media were dissolved in ammonium bicarbonate containing 4 M urea, and proteins were de-salted by acetone-precipitation and subjected to proteome analysis.
ORGANISM(S): Homo Sapiens (human) 
2025-01-01 | PXD045369 | JPOST Repository
TranscriptomicsMicroarray correpsonding to the paper manuscript titled: Targeted expression profiling of single disseminated cancer cells isolated from bone marrow of prostate cancer patients
Bone is the most frequent site of metastasis in prostate cancer (PCa) and patients with bone metastases are deemed incurable. Targeting prostate cancer cells that disseminated to the bone marrow (BM) prior to surgery and before metastatic outgrowth may therefore prevent lethal metastasis. This promp...
ORGANISM(S): Homo sapiens 
2014-10-20 | E-GEOD-59631 | biostudies-arrayexpress
TranscriptomicsAltered expression of microRNAs in bone metastasis compared with human prostate cancer
The principal problem arising from prostate cancer (PCa) is its propensity to metastasize to bone. MicroRNAs (miRNAs) play a crucial role in many tumor metastases.The importance of miRNAs in bone metastasis of PCa has not been elucidated to date. We investigated whether the expression of certain miR...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-26964 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal prostate tissue adjacent to tumor
Prostate cancer is characterized by heterogeneity in the clinical course that often does not to correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can relia...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6608 | biostudies-arrayexpress
ProteomicsExploring the molecular mechanism of bone metastasis in prostate cancer
This study focuses on bone metastasis of prostate cancer. By analyzing clinical samples and serum samples, it aims to reveal key molecular mechanisms and explore diagnostic and therapeutic targets. The specific goals include: First, identifying molecular markers related to bone metastasis, using hig...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD074143 | Pride
Bone metastasis Prostate cancer 
TranscriptomicsTranscription profiling of human primary prostate tumor
Prostate cancer is characterized by heterogeneity in the clinical course that often does not to correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can relia...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6606 | biostudies-arrayexpress
TranscriptomicsGene Expression analysis of castration-resistant prostate cancer bone metastases
Analysis of bone metastases tissue from castration-resistant prostate cancer patients at the RNA level in relation to expression of constitutively active androgen receptor variants termed AR-V7 and AR-V567es. Total RNA obtained from frozen bone metastases samples were analyzed using a gene expressio...
ORGANISM(S): Homo sapiens 
2011-06-02 | E-GEOD-29650 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal prostate tissue free of any pathological alteration
Prostate cancer is characterized by heterogeneity in the clinical course that often does not to correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can relia...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6604 | biostudies-arrayexpress
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