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MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
ProteomicsStructure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating membrane drug targets that cannot be fully inhibited using traditional inhibitors. Several ingenious chimeras have been developed...
ORGANISM(S): Homo Sapiens 
2025-03-04 | PXD061425 |
GenomicsRUNX1 knockdown and BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mtRUNX1 AML cells
RUNX1 knockdown and BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mtRUNX1 AML cells
PRJNA488623 | ENA
UnknownProteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy.
Not available
S-EPMC7218526 | biostudies-literature
UnknownChemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).
Not available
S-EPMC5555382 | biostudies-literature
ProteomicsNovel proteolysis targeting chimera (PROTAC) selectively targeting Leucine Zipper-bearing Kinase (LZK) limits oncogenic potential of head and neck cancers.
Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catal...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD054481 | Pride
Leucine zipper-bearing kinase Lzk Head and neck cancer Targeted protein degradation Protac Map3k13 Proteolysis targeting chimera Hnscc 
UnknownSpecific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC).
Not available
S-EPMC12755880 | biostudies-literature
UnknownRational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC).
Not available
S-EPMC11874035 | biostudies-literature
UnknownProteolysis-Targeting Chimera (PROTAC): Is the Technology Looking at the Treatment of Brain Tumors?
Not available
S-EPMC8886235 | biostudies-literature
UnknownBridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets.
Not available
S-EPMC9772293 | biostudies-literature
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