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TranscriptomicsCombinatorial interactions between viral proteins expand the potential functional landscape of the tomato yellow leaf curl virus proteome
Viruses manipulate the cells they infect in order to replicate and spread. Due to strict size restrictions, viral genomes have reduced genetic space; how the action of the limited num- ber of viral proteins results in the cell reprogramming observed during the infection is a long- standing question....
ORGANISM(S): Nicotiana benthamiana 
2025-09-29 | GSE309527 | GEO
ProteomicsDrosophila Testis Proteome - Stage-specific testes proteomics of Drosophila melanogaster identifies essential proteins for male fertility
Spermiogenesis in Drosophila melanogaster is a highly conserved process and essential for male fertility. In this haploid phase of spermatogenesis, motile sperm are assembled from round cells, flagella are assembled, and needle-shaped nuclei with highly compacted genomes are formed. We aimed at iden...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-02-01 | PXD010627 | Pride
Pupal Larvae Adult Tests 
ProteomicsChallenging the Astral mass analyzer – up to 5300 proteins per single-cell at unseen quantitative accuracy to study cellular heterogeneity.
A detailed proteome map is crucial for understanding molecular pathways and protein functions. Despite significant advancements in sample preparation, instrumentation, and data analysis, single-cell proteomics is currently limited by proteomic depth and quantitative performance. We combine a zero de...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2025-01-16 | PXD049412 | Pride
Liquid chromatography Mass spectrometry Astral A549 Aurora column Single-cell proteomics Trophectoderm-like cells Naïve human stem cells 
ProteomicsChallenging the Astral mass analyzer – up to 5300 proteins per single-cell at unseen quantitative accuracy to study cellular heterogeneity.
This is an additional dataset to PXD049412 A detailed proteome map is crucial for understanding molecular pathways and protein functions. Despite significant advancements in sample preparation, instrumentation, and data analysis, single-cell proteomics is currently limited by proteomic depth and qua...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD064564 | Pride
Mass spectrometry Astral A549 Liquid chromatography Aurora column Single-cell proteomics Trophectoderm-like cells Naïve human stem cells 
ProteomicsIn Vitro Investigation of The Anti-Fibrotic Potential of 1-Phenyl-2-Pentanol, Identified from Moringa Oleifera Lam. on Hepatic Stellate Cells
Liver fibrosis, characterized by excessive extracellular matrix deposition, is driven by activated hepatic stellate cells (HSCs). Due to the limited availability of anti-fibrotic drugs, research con-tinues to explore potential therapeutic agents. Moringa oleifera Lam. (MO), known for its various bio...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD052809 | Pride
Hepatic stellate cell Liver fibrosis Moringa oleifera lam. Molecular docking analysis Proteomics 1-phenyl-2-pentanol Lc-ms/ms 
ProteomicsA decision tree searching strategy to boost the identification of cross-linked peptides
We describe an efficient decision tree searching strategy (DTSS) to boost the identification of cross-linked peptides. The DTSS approach allows the identification of a wealth of complementary information to facilitate the construction of more protein-protein interaction networks for human cell lysat...
ORGANISM(S): Escherichia coli 
2020-11-23 | PXD018291 | Pride
Xlink-ms Data-analysis 
ProteomicsNanodiamond Solid Phase Extraction and Triton X-114 Cloud Point Separation for Robust Fractionation and Shotgun Proteomics Analysis of Human Serum Proteome
Human serum is one of the most attractive specimens in biomarker research. However, its overcomplicated properties have hindered the analysis of low-abundance proteins by conventional mass spectrometry techniques. This work proposes an innovative strategy for utilizing nanodiamonds (NDs) in combinat...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD029710 | Pride
Proteomic analysis Cloud point separation Triton x-114 Prote-ome Nanodiamond Fractionation Solid phase extraction Human serum Lc-ms/ms 
GenomicsCombinatorial interactions between viral proteins expand the potential functional landscape of the tomato yellow leaf curl virus proteome
Combinatorial interactions between viral proteins expand the potential functional landscape of the tomato yellow leaf curl virus proteome
PRJNA1336208 | ENA
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