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ProteomicsSnake venom serine proteinases specificity mapping by proteomic identification of cleavage sites
Serine proteinases have been shown to play the role of toxins in the venoms of many snakes. They act mainly on components of the coagulation cascade, and fibrinolytic and kallikrein-kinin systems to trigger various pathological effects observed in the envenomation. Despite showing high similarity in...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2014-10-30 | PXD001217 | Pride
Serine proteinase Pproteomic identification of protease cleavage sites Mass spectrometry Snake venom Proteinase 
TranscriptomicsPaf1C plays novel subunit-specific roles in alternative cleavage and polyadenylation
The PAF complex (Paf1C) has been shown to regulate chromatin modifications, gene transcription, and PolII elongation. Here, we provide the first genome-wide analysis of chromatin occupancy by the entire PAF complex in mammalian cells. We show that Paf1C is recruited not only to promoters and gene bo...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-72574 | biostudies-arrayexpress
ProteomicsTAILS identifies candidate substrates and biomarkers of ADAMTS7, a therapeutic protease target in coronary artery disease
MacDonald BT, Keshishian H, Mundorff CC, Arduini A, Lai D, Bendinelli K, Popp NR, Bhandary B, Clauser KR, Specht H, Elowe NH, Laprise D, Xing Y, Kaushik VK, Carr SA, Ellinor PT. Loss-of-function mutations in the secreted enzyme ADAMTS7 (a disintegrin and metalloproteinase with thrombospondin motifs ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-03 | MSV000088508 | MassIVE
ProteomicsStability of the neuronal fate determinant MEIS2 is controlled by calpain2
Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are associated with various cellular functions but have so far been mainly studied in the context of disease. Their contribution to homeostasis in the healthy organism is still not well understood and their substrates have remained...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-02-08 | PXD036442 | Pride
Stem cell Protease cleavage sites Meis2 Calpain Subventricular zone Phosphoproteomics Adult neurogenesis 
ProteomicsActive Site Specificity Profiling of the Matrix Metalloproteinase Family: Proteomic Identification of 4,300 Cleavage Sites by MMPs 1, 2, 3, 7, 8, 9, 12, 13, and 14.
Background: The active site of matrix metalloproteinases (MMPs) is highly conserved, complicating the rational design of specific substrates and inhibitors for individual family members. Results: Active site specificity profiles of 9 MMPs were determined using high throughput Proteomic Identificatio...
ORGANISM(S): Homo sapiens (Human) 
2015-09-29 | PXD002265 | Pride
Ecm Pics Mmps Mass spectrometry Specificity profiling Webpics 
UnknownDataset of cocoa aspartic protease cleavage sites.
Not available
S-EPMC4950170 | biostudies-literature
ProteomicsHERV protease specificity - Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics
Proteome-derived peptide libraries are a powerful tool for the investigation of protease specificity, conventionally involving the biotinylation of cleavage products to enable for their enrichment. Here we present a modified strategy for protease specificity profiling using proteome-derived peptide ...
ORGANISM(S): Escherichia coli 
2016-05-02 | PXD003833 | Pride
Protease 
UnknownPrediction of coronavirus 3C-like protease cleavage sites using machine-learning algorithms.
Not available
S-EPMC9060714 | biostudies-literature
ProteomicsIdentification C3 cleavage sites by alpha-Thrombin
Identification C3 cleavage sites by alpha-Thrombin. Goal of the experiment is the validation of predicted cleavage sites by HTPS
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD022971 | Pride
Htps Cleavages identification 
ProteomicsN-terminal acetylation for identification of cleavage sites on immunoprecipitated PrP
In-gel N-terminal acetylation of immunoprecipitated prion protein for identification of cleavage sites. Mouse expressing either WT or mutant (S3) form of PrP were used in this study. Three replicates from single brains were included in this experiment.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-07-27 | MSV000092543 | MassIVE
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