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ProteomicsOrientia tsutsugamushi proteome profile host context
Emerging and neglected pathogens pose challenges as their biology is frequently poorly understood, and genetic tools often do not exist to manipulate them. Organism agnostic sequencing technologies offer a promising approach to understand the molecular processes underlying these diseases. Here we ap...
ORGANISM(S): Cellular Organisms 
2020-06-05 | PXD017956 | JPOST Repository
ProteomicsNetwork of interactions between ZIKA virus non-structural proteins and human host proteins
The Zika virus (ZIKV) is a mosquito-borne Flavivirus and can be transmitted through an infected mosquito bite or through human-to-human interaction by sexual activity, blood transfusion, breastfeeding or perinatal exposure. After the 2015-2016 outbreak in Brazil, a strong link between ZIKV infection...
ORGANISM(S): Homo sapiens (Human) 
2020-06-18 | PXD014961 | Pride
Zikv Non-structural viral proteins Network Protein-protein interaction 
ProteomicsStabilization of Interdomain Interactions in G protein α Subunits as a Determinant of Gαi Subtype Signaling Specificity
Highly homologous members of the Gαi family, Gαi1-3, have distinct tissue distributions and physiological functions, yet their biochemical and functional properties are very similar. We recently identified PDZ-RhoGEF (PRG) as a novel Gαi1 effector that is poorly activated by Gαi2. In a proteomic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD050824 | Pride
Heterotrimeric g protein Proximity labeling Mass spectrometry Structure. G protein-coupled receptor Effector coupling Rho gef Domain interactions Alpha subunits 
ProteomicsDysregulation of Cell-Cell Interaction in Brain Arteriovenous Malformations: A Quantitative Proteomics Study
Object. Detailed and exact mechanisms underlying brain arteriovenous malformations (bAVM) are still confusing in clinic. Understanding the quantitative changes of proteins and signaling pathways would provide useful information for clinicians to understand the formation and development of bAVM and t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080716 | MassIVE
ProteomicsSpatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors
Precise dissection of DNA-protein interactions is essential for elucidating recognition basis, dynamics, and gene regulation mechanism. However, global profiling of weak and dynamic DNA-protein interactions remains a long-standing challenge. Here, we establish light-induced lysine (K) enabled crossl...
ORGANISM(S): Homo Sapiens 
2023-01-03 | PXD039229 |
ProteomicsValidation of a novel shotgun proteomic workflow for the discovery of protein-protein interactions: focus on ZNF521
The study of protein-protein interactions is increasingly relying on mass spectrometry (MS). The classical approach of separating immunoprecipitated proteins by SDS-PAGE followed by in-gel digestion is long and labour-intensive. Besides, it is difficult to integrate it with most quantitative MS-base...
ORGANISM(S): Homo sapiens (Human) 
2015-04-07 | PXD001609 | Pride
Ap-ms  interactomics  18o labelling  znf521  znf423  spt16  spt5  nurd core complex  proteomics  mass spectrometry  shotgun proteomics 
ProteomicsCrosslinking mass spectrometry unveils novel interactions and structural distinctions in the model green alga Chlamydomonas reinhardtii
Interactomics is an emerging field that seeks to identify both transient and complex-bound protein interactions that are essential for metabolic functions. Crosslinking mass spectrometry (XL-MS) has enabled untargeted global analysis of these protein networks, permitting largescale simultaneous anal...
ORGANISM(S): Chlamydomonas reinhardtii 
2021-11-03 | PXD026433 | Pride
Chlamydomonas Photosynthesis Crosslinking mass spectrometry Interactome Lc-ms/ms 
ProteomicsDeciphering the roles of N-glycans on collagen-platelet interactions
Collagen is a potent agonist for platelet activation, presenting itself as a key contributor to coagulation via interactions with platelet glycoproteins. The fine-details dictating platelet-collagen interactions are poorly understood. In particular, glycosylation could be a key determinant in the pl...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2019-06-14 | PXD010290 | Pride
Collagen Protein interactions Glycans Platelets 
ProteomicsContext-dependent phosphorylation of CSDE1 drives interactions with ribosomes
The RNA-binding protein CSDE1 is a key regulator of mRNA stability and translation in a broad spectrum of biological processes. We have previously shown that CSDE1 functions as an oncoprotein promoting invasion and metastasis in melanoma, whereas it behaves as a tumour suppressor promoting cellular ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-10 | PXD062774 | Pride
Csde1 Melanoma Phosphorylation 
ProteomicsJMJD2 regulates enhancer-promoter interactions via biocondensate formation
Enhancer-promoter (E-P) interactions regulate transcription for cell fate determination. However, the regulatory mechanisms of E-P interactions remain elusive. Here, a chromatin interaction-based proteomics approach, LoopID, was developed to profile the proteins at certain E-P anchors, which were te...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD069064 | Pride
Enhancer-promoter interactions Proximity ligation Loopid Biocondensates Proteome 
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