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MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
ProteomicsAcetylome analysis of Bordetella pertussis reveals possible targets of novel BP0960 gene-encoded lysine deacetylase
Acetylation on ε-amino groups of lysine residues (N-ε-lysine acetylation) represents an important mechanism of post-translational regulation of protein function. However, its role and extent in the whooping cough agent Bordetella pertussis remain unknown. In this study, we analyzed the acetylomes of...
ORGANISM(S): Bacteria Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2020-07-19 | PXD016384 | Pride
Acetylome Bordetella pertussis Deacetylase activity 
UnknownTime-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome.
Not available
S-EPMC6078418 | biostudies-literature
ProteomicsHigh intensity interval training remodels the proteome and acetylome in human skeletal muscle
Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD023084 | Pride
Lysine acetylation Exercise Proteome Skeletal muscle Lcms 
ProteomicsRegulation of cellular proteome and acetylome by catalytic and non-catalytic functions of class I histone deacetylases
Project description: Taking advantage of a newly generated model system, we examined the influence of class I HDAC catalytic and non-catalytic function on the cellular proteome and acetylome. Therefore, we generated HAP1 cell lines either lacking individual class I HDACs or expressing catalytically ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-16 | PXD030164 | Pride
Acetylome Chromatin Hdac inhibitor Histone deacetylase 
UnknownHigh-intensity interval training remodels the proteome and acetylome of human skeletal muscle.
Not available
S-EPMC9154743 | biostudies-literature
ProteomicsIntegrating multi-omics analyses unveil protein features of gestational diabetes mellitus and preeclampsia
As one of the most common maternal comorbidities, gestational diabetes mellitus (GDM) and preeclampsia (PE) are associated with maternal and infant health. Although the pathogenesis of PE and GDM remains controversial, oxidative stress is thought to be involved in the underlying pathology of GDM and...
ORGANISM(S): Homo sapiens (Human) 
2024-01-25 | PXD032981 | Pride
Lysine acetylation Proteomics Gestational diabetes mellitus Preeclampsia Oxidative stress 
Proteomics: The Tip60 acetylome is a hallmark of the proliferative state in Drosophila
The acetyltransferase KAT5/Tip60 is a key epigenetic regulator of transcription and the DNA damage response. In Drosophila, Tip60 functions within the DOM-A complex to acetylate histones, but its broader substrate repertoire and cellular roles remain incompletely defined. Here, we comprehensively in...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-07-16 | PXD066107 | Pride
Acetylome Drosophila Tip60 Proliferation 
ProteomicsProfiling of mouse sciatic nerve acetylome
Lysine acetylation is a reversible Post-translational modification (PTM) involved in a broad array of physiological functions. Recent studies have demonstrated the involvement of protein acetylation in modulating Schwann cells' (SCs) biology and the peripheral nervous system (PNS) regeneration. Howe...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD029611 | Pride
Acetylome Sciatic nerve Mouse Acetylation Schwann cells 
ProteomicsTime-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators; however, their acetylation targets, site-specific acetylation kinetics, and function in proteome regulation are incompletely understood. We combined quantitative proteomics with novel CBP/p300-specific catalytic i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
MSV000095981 | MassIVE
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