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ProteomicsShotgun proteomics analysis of protein purifications from human plasma using antibodies and affimers
Antibodies are widely used to purify protein from complex mixtures like human plasma. Assessing the specificity of anntibodies, or any protein binder, is essential for the development of a protein biomarker assay. In addition to antibodies, novel protein binders like affimers are developed with a hi...
ORGANISM(S): Homo sapiens (Human) 
2020-05-29 | PXD016435 | Pride
Antibody Protein purification Affimer Lc-ms/ms 
ProteomicsSpecies-specific cleavage of the autophagy adaptor p62 dictates responses to TNF
Inflammation is a driver of many diseases including cancer. Several studies have also shown that changes to macroautophagy can affect inflammation. We were interested in these connections and we report here that the autophagy adaptor proteins p62/SQSTM1 is cleaved upon treatment with the inflammat...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD065587 | Pride
Autophagy Tnf Inflammation Caspase Protein cleavge Apoptosis P62 
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