Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse NIH3T3 cells over-expressing RNA-dependent serine/threonine protein kinase (PKR)PKR
Global analysis of gene expression in NIH3T3 cells over-expressing RNA-dependent serine/threonine protein kinase (PKR).
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-682 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human NIH 3T3 inducible cell line to study the role of PKR in regulating gene expression
PKR is an interferon induced serine/threonine protein kinase, that is activated by double stranded RNA. PKR plays an important role in the antiviral defense by interferon. In addition to its role in translation, PKR participates in several signaling pathways to transcription. The goal of this experi...
ORGANISM(S): Mus musculus 
2004-01-30 | E-MEXP-50 | biostudies-arrayexpress
TranscriptomicsA potential role for snoRNA in PKR activation during metabolic stress
PKR (Protein Kinase RNA-activated) is activated by metabolic stress, such as that associated with obesity, and this activation depends on its RNA-binding domain. Here we investigated whether endogenous RNA triggers PKR activation in response to lipid exposure. Our results indicate that snoRNAs (smal...
ORGANISM(S): Mus musculus 
2015-05-08 | E-GEOD-66540 | biostudies-arrayexpress
ProteomicsCardiovirus-Mediated PKR Inhibition Results from Nucleocytoplasmic Trafficking Disruption
Protein kinase R (PKR) is a key antiviral kinase activated by binding double-stranded RNA (dsRNA) produced during viral replication. Upon activation, PKR phosphorylates eIF2α, leading to the inhibition of translation and viral replication. However, many viruses have evolved mechanisms to counteract ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD066206 | Pride
Nucleocytoplasmic traffic Pkr Nucleocytoplasmic trafficking disorder (nctd) Cardiovirus Stress granules. Picornavirus Nucleoli Double-stranded rna Eif2ak2 
ProteomicsSuppression of the nucleic acid precursor ribose 5-phosphate by RNA-mediated antiviral immunity.
We identify that the antiviral protein kinase PKR alters glycolysis. This response is found to be independent of the kinase’s established control of gene expression that is executed through phosphorylation of the Eukaryotic Translation Initiation Factor 2. Instead, a novel substrate is recognised wi...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD036779 | Pride
Metabolism Protein kinase r pkr Ribose 5-phosphate isomerase Antiviral immunity 
ProteomicsEssential role of Protein kinase R in the pathogenesis of pulmonary veno-occlusive disease
Pulmonary veno-occlusive disease (PVOD) is a rare and severe form of pulmonary arterial hypertension, characterized by progressive obstruction of small pulmonary vessels and a lack of effective therapeutic options. Our previous research, utilizing a mitomycin C (MMC)-induced rat model, demonstrated ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-11 | PXD066782 | Pride
Protein kinase r Proteomics Pvod 
TranscriptomicsExpressed dsRNA provokes selective sequence-independent PKR response in transient co-transfection experiments
In mammals, double-stranded RNA (dsRNA) plays roles in sequence-specific RNA interference, sequence-independent interferon response, and RNA editing by adenosine deaminases. We have previously shown that long hairpin dsRNA expression in cultured cells does not activate the interferon response, it is...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-46959 | biostudies-arrayexpress
ProteomicsIFN alpha inducible protein 27 (IFI27) acts as a positive regulator of PACT-dependent PKR activation after RNA virus infections
Protein kinase R (PKR) expression is induced by interferons. This protein is activated by double-stranded (ds) RNAs or RNAs containing duplex regions, produced after different stimuli, such as after viral infections, leading to the phosphorylation of the eukaryotic translation initiation factor 2α (...
ORGANISM(S): Homo Sapiens (human) 
2026-10-22 | PXD086108 | JPOST Repository
UnknownThe search for a PKR code-differential regulation of protein kinase R activity by diverse RNA and protein regulators.
Not available
S-EPMC6467004 | biostudies-literature
GenomicsProtein Kinase R regulates pancreatic ductal adenocarcinoma progression by modulating the cell cycle via GADD45A
Protein Kinase R regulates pancreatic ductal adenocarcinoma progression by modulating the cell cycle via GADD45A
PRJNA1207023 | ENA
Sort   by:  
 Page size