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ProteomicsExpression dynamics in mammalian cells responding to protein misfolding stress
The relative importance of gene expression regulation at the mRNA versus the protein-level is a matter of ongoing debate. We present an in-depth analysis of a cervical cancer cell line responding to protein misfolding stress induced by dithiothreitol treatment, quantifying the dynamics of mRNA and p...
ORGANISM(S): Homo sapiens (Human) 
2016-03-14 | PXD002039 | Pride
Human Lc-msms Protein misfolding stress Hela 
GenomicsDELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq]
DELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq]
PRJNA1141402 | ENA
GenomicsRedox control of the cAMP/PKA pathway during protein misfolding stress
Redox control of the cAMP/PKA pathway during protein misfolding stress
PRJEB39415 | ENA
ProteomicsCell survival and adaptation to chronic endoplasmic reticulum stress in thyrocytes
The large secretory glycoprotein, thyroglobulin, is the primary translation product of thyroid follicular cells. This difficult-to-fold protein is readily susceptible to structural alterations that render the misfolded thyroglobulin unable to be exported from the endoplasmic reticulum (ER) a known c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-25 | MSV000085006 | MassIVE
TranscriptomicsRedox control of the cAMP/PKA pathway during protein misfolding stress
Protein aggregation is the abnormal association of misfolded proteins into larger, often insoluble structures that can be toxic during ageing and in protein aggregation-associated diseases. This RNA-seq study in Saccharomyces cerevisiae investigated the role of Tsa1, which is a member of the highly ...
ORGANISM(S): Saccharomyces cerevisiae 
2021-04-19 | E-MTAB-9355 | biostudies-arrayexpress
TranscriptomicsDELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq]
Transcriptional mitochondrial stress response to CHCHD10 G58R protein misfolding in mouse heart, gastrocnemius, and tibalis anterior muscle the presence and absence of the DELE1 mitochondrial integrated stress responses
ORGANISM(S): Mus musculus 
2024-07-31 | GSE273310 | GEO
TranscriptomicsExpression dynamics in mammalian cells responding to protein misfolding stress
We have employed whole genome microarray expression profiling to track the transcriptome expression change under DTT induced protein misfolding stress. The relative importance of gene expression regulation at the mRNA versus the protein-level is a matter of ongoing debate. We present an in-depth ana...
ORGANISM(S): Homo sapiens 
2015-08-15 | GSE67901 | GEO
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75247 | biostudies-arrayexpress
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75410 | biostudies-arrayexpress
GenomicsTranscriptional stress responses induced by compartment-targeted misfolding-prone proteins in Drosophila
Transcriptional stress responses induced by compartment-targeted misfolding-prone proteins in Drosophila
PRJNA1017426 | ENA
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