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TranscriptomicsAbsolute quantification of protein production reveals principles underlying protein synthesis rates
A quantitative view of cellular functions requires precise measures of the rates of biomolecule production, especially proteins-the direct effectors of biological processes. Here we present a genome-wide approach, based on ribosome profiling, for measuring absolute protein synthesis rates. The resul...
ORGANISM(S): Escherichia coli 
2014-04-24 | E-GEOD-53767 | biostudies-arrayexpress
ProteomicsChanges in Protein Turn-over Rates Regulate Tryptophan and Glucosinolate Biosynthesis, IAA Transport and Photosynthesis in Arabidopsis Growth and Defense Transitions
Changes in protein synthesis and degradation rates, transcript, protein and phytohormone abundance of 99 targets using qPCR and LC-MS parallel reaction monitoring (PRM) were measured in the transitions between optimal growth conditions (homeostasis), fully induced pattern triggered immunity (PTI) an...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-10-13 | PXD041215 | Pride
Translational regulation Photosynthesis Protein degradation rates Pti Glucosinolates Myc2 Phytohormone Proteomics Protein synthesis rates Auxin Pin proteins 
MetabolomicsThe Impact of Ethnicity and Intra-Pancreatic Fat on the Postprandial Metabolome Response to Whey Protein in Overweight Asian Chinese and European Caucasian Women with Prediabetes
The 'Thin on the Outside Fat on the Inside' TOFI_Asia study found Asian Chinese to be more susceptible to Type 2 Diabetes (T2D) compared to European Caucasians matched for gender and body mass index (BMI). This was influenced by degree of visceral adipose deposition and ectopic fat accumulation in k...
2022-10-12 | MTBLS5568 | MetaboLights
ProteomicsProtein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates
Although protein synthesis dynamics has been studied both with theoretical models and by profiling ribosome footprints, the determinants of ribosome flux along open reading frames (ORFs) are not fully understood. Combining measurements of protein synthesis rate with ribosome footprinting data, we he...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-09-10 | PXD014357 | Pride
Protein charge Yeast Translation Tasep Ribosomal proteins 
ProteomicsIn utero pulse-injection of isotopic amino acids quantifies protein turnover rates during murine fetal development
Protein translational control is a highly regulated step in the gene expression program during development and tools to quantify protein synthesis rates in a developing fetus are lacking. Here, we developed a novel in utero approach to quantify tissue-specific translational kinetics of the nascent p...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-04-30 | MSV000087342 | MassIVE
MetabolomicsDietary carbohydrate and protein levels affect the growth performance of juvenile peanut worm (Sipunculus nudus): an LC–MS-based metabolomics study
The peanut worm (Sipunculus nudus) is an economically important fishery resource in China. To determine how dietary carbohydrate and protein levels affects the growth performance of juvenile S. nudus and identify the mechanisms underlying observedpatterns, five isoenergetic and isolipidic diets with...
2021-07-16 | MTBLS2887 | MetaboLights
GenomicsNitric oxide required for transition to slower hepatic protein synthesis rates during long-term caloric restriction
Nitric oxide required for transition to slower hepatic protein synthesis rates during long-term caloric restriction
PRJNA1147329 | ENA
ProteomicsProtein synthesis during myoblast differentiation
Mole (MSR) and fractional (FSR) synthesis rates of proteins during C2C12 myoblast differentiation were investigated. Myoblast cultures supplemented with D2O during 0-24 h or 72-96 h of differentiation were analysed by LC-MS/MS to calculate protein FSR and MSR after samples were spiked with yeast alc...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021125 | Pride
C2c12  muscle  fractional synthesis rate 
GenomicsCoordination of protein synthesis and decay in mammalian cells
Coordination of protein synthesis and decay in mammalian cells
PRJNA1169773 | ENA
TranscriptomicsAbsolute quantification of protein production reveals principles underlying protein synthesis rates
A quantitative view of cellular functions requires precise measures of the rates of biomolecule production, especially proteins-the direct effectors of biological processes. Here we present a genome-wide approach, based on ribosome profiling, for measuring absolute protein synthesis rates. The resul...
ORGANISM(S): Escherichia coli 
2014-04-24 | GSE53767 | GEO
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