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ProteomicsStructure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating membrane drug targets that cannot be fully inhibited using traditional inhibitors. Several ingenious chimeras have been developed...
ORGANISM(S): Homo Sapiens 
2025-03-04 | PXD061425 |
GenomicsTumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription
Using EWS-FLI and its parental transcription factor, FLI1, we created a unique experimental system to address questions regarding the genomic mechanisms by which chimeric transcription factors cause cancer. We found that in tumor cells, EWS-FLI targets regions of the genome distinct from FLI1, despi...
ORGANISM(S): Homo sapiens 
2011-11-09 | E-GEOD-31838 | biostudies-arrayexpress
GenomicsRUNX1 knockdown and BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mtRUNX1 AML cells
RUNX1 knockdown and BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mtRUNX1 AML cells
PRJNA488623 | ENA
ProteomicsNovel proteolysis targeting chimera (PROTAC) selectively targeting Leucine Zipper-bearing Kinase (LZK) limits oncogenic potential of head and neck cancers.
Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catal...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD054481 | Pride
Leucine zipper-bearing kinase Lzk Head and neck cancer Targeted protein degradation Protac Map3k13 Proteolysis targeting chimera Hnscc 
ProteomicsIdentification of protein substrates of a novel proteolysis targeting chimera, PROTAC124 in tongue squamous cell carcinoma cell line CAL-33 overexpressing Leucine Zipper-bearing Kinase (LZK).
Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catal...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD057778 | Pride
Map3k13) Head and neck cancer Targeted protein degradation Protac (proteolysis targeting chimera) Hnscc Leucine zipper-bearing kinase (lzk 
UnknownLeveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera.
Not available
S-EPMC11638965 | biostudies-literature
UnknownModular Assembled Targeting Chimera Enables Multimodal Targeted Protein Degradation.
Not available
S-EPMC12648310 | biostudies-literature
UnknownProteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy.
Not available
S-EPMC7218526 | biostudies-literature
GenomicsBioresponsive lysosome-targeting chimeras for targeted protein degradation
Bioresponsive lysosome-targeting chimeras for targeted protein degradation
PRJNA1256450 | ENA
TranscriptomicsRUNX1 knockdown and BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mtRUNX1 AML cells
Bromodomain extraterminal protein (BETP) inhibitors transcriptionally repress oncoproteins which undermines the growth and survival of AML cells. However, BETi treatment causes accumulation of BETPs, associated with reversible binding and incomplete inhibition of BRD4, which potentially compromises ...
ORGANISM(S): Homo sapiens 
2020-08-11 | GSE119261 | GEO
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