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TranscriptomicsQuantitative real-time RT-PCR analysis of HEK293 cells stably transfected with PRL-1 (PTP4A1) or empty pcDNA4 vector control.
The protein tyrosine phosphatase PRL-1 (Gene Symbol: PTP4A1) has been identified as an important oncogene with roles in promoting cell proliferation, survival, migration, invasion, and metastasis. However, little is currently known about the signaling pathways through which it mediates its effects...
ORGANISM(S): Homo sapiens 
2013-07-30 | E-GEOD-42587 | biostudies-arrayexpress
TranscriptomicsMapping and characterization of promoter-binding sites of protein phosphatase 1
Protein phosphatase 1 (PP1) is a Ser/Thr phosphatase that has been implicated in many key cellular functions including transcriptional regulation. Due to its involvement these many processes, it becomes difficult to directly link PP1 to transcriptional regulation on the chromatin level as no direct ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-54170 | biostudies-arrayexpress
ProteomicsInvolvement of low molecular weight tyrosine acid phosphatase in abscisic acid signaling in Arabidopsis
Low molecular weight protein tyrosine phosphatase (LWM-PTP) is highly conserved tyrosine phosphatase from plants to animals. The function and putative targets of plant LWM-PTP homolog is not reported yet. Here, we revealed that Arabidopsis LWM-PTP homolog APH is a functional tyrosine phosphatase. AP...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-10-14 | PXD029650 | Pride
Homolog Tyrosine phosphorylation Low molecular weight protein tyrosine phosphatase 
TranscriptomicsIntegrative transcriptome profiling of cognitive aging and its preservation through Ser/Thr protein phosphatase regulation
Environmental enrichment has been reported to delay or restore age-related cognitive deficits, however, a mechanism to account for the cause and progression of normal cognitive decline and its preservation by environmental enrichment is lacking. Using genome-wide SAGE-Seq, we provide a global assess...
ORGANISM(S): Mus musculus 
2015-06-24 | E-GEOD-43718 | biostudies-arrayexpress
ProteomicsThe Arabidopsis tyrosine phosphatase RLPH2 targets D-group MAP kinases
Knowing that biochemically RLPH2 is a tyrosine phosphatase, we selectively In an attempt to discover RLPH2 substrates we decided to use the power of phospho-proteomics. Immunoprecipitated tyrosine phosphorylated peptides from enriched phospho-peptide pools derived from these plant extracts. Mass spe...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-01-26 | PXD038689 | Pride
Phosphoproteomics Arabidopsis Protein phosphatase Mapk 
MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
ProteomicsA Global Analysis of Receptor Tyrosine Kinase – Protein Phosphatase Interactome
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. However, a comprehensive picture of how RTKs functionally associate with phosphatases remains elusive. We aimed to study this problem by using two protein-protein interactio...
ORGANISM(S): Homo sapiens (Human) 
2017-01-11 | PXD004248 | Pride
Tyrosine kinaase Phosphatase interactome 
ProteomicsIdentification of Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1) protein partners using Tandem Affinity Purification and Mass Spectrometry
According to the World Health Organization Report, depressive disorders affect about 10% of the population. The molecular mechanism of the pathogenesis of depression is still not well understood. The new findings point to phosphatases as potential targets for effective depression therapy. The aim of...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-19 | MSV000091093 | MassIVE
TranscriptomicsTranscription profiling of mouse spleen from animals exposed to Ebola virus reveals reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection
To gain insight into the changes in gene expression pattern upon Ebola infection, CD45+/+ (100% protein level) and CD45+/- (62% protein level) mice were challenged with mouse adapted Ebola virus. At time-points day 0, 1, 3, 5, 7, 9, 11 and 13, spleen tissue was harvested and splenocytes isolated. To...
ORGANISM(S): Mus musculus 
2009-09-05 | E-GEOD-17509 | biostudies-arrayexpress
ProteomicsS-nitrosation of Arabidopsis thaliana Protein Tyrosine Phosphatase 1 (AtPTP1) prevents its irreversible oxidation by hydrogen peroxide
Tyrosine-specific protein tyrosine phosphatases (Tyr-specific PTPases) are key signalling enzymes catalyzing the removal of the phosphate group from phosphorylated tyrosine residues on target proteins. This post-translational modification notably allows the regulation of mitogen-activated protein ki...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-04-04 | PXD030071 | Pride
Arabidopsis thaliana Post-translational modifications Protein tyrosine phosphatase 1 S-nitrosation Oxidation H2o2 Mitogen-activated protein kinases Nitric oxide 
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